Resuscitation with hydroxyethyl starch improves renal function and lactate clearance in penetrating trauma in a randomized controlled study: the FIRST.

Slides:

Advertisements

Similar presentations

Assessment of standard laboratory tests and rotational thromboelastometry for the prediction of postoperative bleeding in liver transplantation T.M.

Advertisements

Effects of intraoperative and early postoperative normal saline or Plasma-Lyte 148® on hyperkalaemia in deceased donor renal transplantation: a double-blind.

Towards a framework for organ donation in the UK

Recombinant activated factor VII and prothrombin complex concentrates have different effects on bleeding and arterial thrombosis in the haemodiluted rabbit

von Roten I , Madjdpour C , Frascarolo P , Burmeister M. -A

J.H. Ryu, S.W. Lee, J.H. Lee, E.H. Lee, S.H. Do, C.S. Kim

The effects of i.v. fentanyl administration on the minimum alveolar concentration of isoflurane in horses Thomasy S.M. , Steffey E.P. , Mama K.R. , Solano.

A. Butwick, G. Hilton, B. Carvalho British Journal of Anaesthesia

Reduction in mortality after epidural anaesthesia and analgesia in patients undergoing rectal but not colonic cancer surgery: a retrospective analysis.

Effect of ventilation on cerebral oxygenation in patients undergoing surgery in the beach chair position: a randomized controlled trial G.S. Murphy,

Effects of maintaining a remifentanil infusion on the recovery profiles during emergence from anaesthesia and tracheal extubation J.-S. Nho, S.-Y. Lee,

Bispectral index-guided induction of general anaesthesia in patients undergoing major abdominal surgery using propofol or etomidate: a double-blind, randomized,

Dexmedetomidine vs propofol-remifentanil conscious sedation for awake craniotomy: a prospective randomized controlled trial† ‡ N Goettel, S Bharadwaj,

Type of anaesthesia and patient quality of recovery: a randomized trial comparing propofol–remifentanil total i.v. anaesthesia with desflurane anaesthesia

K.-Y. Ho, W Tay, M.-C. Yeo, H Liu, S.-J. Yeo, S.-L. Chia, N.-N. Lo

Influence of haemorrhage on the pseudo-steady-state remifentanil concentration in a swine model: a comparison with propofol and the effect of haemorrhagic.

Cost-effectiveness of a systematic e-assessed follow-up of postoperative recovery after day surgery: a multicentre randomized trial K. Dahlberg, A. Philipsson,

M. Zaar, B. Lauritzen, N. H. Secher, T. Krantz, H. B. Nielsen, P. L

Differential effects of lidocaine and remifentanil on response to the tracheal tube during emergence from general anaesthesia J.H. Lee, B.-N. Koo, J.-J.

Does the prophylactic administration of magnesium sulphate to patients undergoing thoracotomy prevent postoperative supraventricular arrhythmias? A randomized.

Effect of a patient blood management programme on preoperative anaemia, transfusion rate, and outcome after primary hip or knee arthroplasty: a quality.

Pharmacokinetics of ropivacaine in patients with chronic renal failure

Perioperative treatment algorithm for bleeding burn patients reduces allogeneic blood product requirements E. Schaden, O. Kimberger, P. Kraincuk, D.M.

Changes in glomerular filtration rate after cardiac surgery with cardiopulmonary bypass in patients with mild preoperative renal dysfunction B.G. Loef,

Thoracic epidural analgesia or patient-controlled local analgesia for radical retropubic prostatectomy: a randomized, double-blind study F. Fant, K.

Impact of sleep deprivation on anaesthesia residents’ non-technical skills: a pilot simulation-based prospective randomized trial A. Neuschwander, A.

Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries British Journal of Anaesthesia

Preoperative supplementation with fibrinogen concentrate in cardiac surgery: A randomized controlled study A. Jeppsson, K. Waldén, C. Roman-Emanuel,

Effects of a recombinant FVIIa analogue, NN1731, on blood loss and survival after liver trauma in the pig M. Zaar, N.H. Secher, P.I. Johansson, B. Vainer,

Blood glucose concentration profile after 10 mg dexamethasone in non-diabetic and type 2 diabetic patients undergoing abdominal surgery Hans P , Vanthuyne.

Malignant hyperthermia: pharmacology of triggering

Do team processes really have an effect on clinical performance

H. J. Kim, H. -C. Lee, Y. S. Jung, J. Lee, J. J. Min, D. -M. Hong, E

I.V. paracetamol as an adjunct to patient-controlled epidural analgesia with levobupivacaine and fentanyl in labour: a randomized controlled study K.

Early or late fresh frozen plasma administration in newborns and small infants undergoing cardiac surgery: the APPEAR randomized trial P. Bianchi, M.

Comparison of the effects of albumin 5%, hydroxyethyl starch 130/0

Coagulopathy and blood component transfusion in trauma

Changes in serum albumin concentration and volume expanding effects following a bolus of albumin 20% in septic patients Margarson M.P. , Soni N.C.

Efficacy and adverse effects of ketamine as an additive for paediatric caudal anaesthesia: a quantitative systematic review of randomized controlled trials†

Combined spinal and epidural anaesthesia and maternal intrapartum temperature during vaginal delivery: a randomized clinical trial F.A. de Orange, Passini.

Isotonic crystalloid solutions: a structured review of the literature

The novel Kv1.5 channel blocker vernakalant for successful treatment of new-onset atrial fibrillation in a critically ill abdominal surgical patient

H. Beloeil, J.-X. Mazoit, D. Benhamou, J. Duranteau

Physiological effects of hyperchloraemia and acidosis

Impact of balanced tetrastarch raw material on perioperative blood loss: a randomized double blind controlled trial† A Joosten, R Tircoveanu, S Arend,

The output of two sevoflurane vaporizers in the presence of helium

Lung recruitment and positive airway pressure before extubation does not improve oxygenation in the post-anaesthesia care unit: a randomized clinical.

Recombinant factor VIIa reduces bleeding after blunt liver injury in coagulopathic, hypofibrinogenaemic pigs O Grottke, T Braunschweig, L Zimmermann,

GlideScope® video laryngoscope: a randomized clinical trial in 203 paediatric patients† J.-T. Kim, H.-S. Na, J.-Y. Bae, D.-W. Kim, H.-S. Kim, C.S. Kim,

II. Should anaesthetists stop infusing isotonic saline?

Damage control surgery in the era of damage control resuscitation

Rapid sequence induction and intubation with rocuronium–sugammadex compared with succinylcholine: a randomized trial M.K. Sørensen, C. Bretlau, M.R.

Bibliometrics of anaesthesia researchers in the UK

G.B. Drummond, B. Lafferty British Journal of Anaesthesia

Effects of acute plasma volume expansion on renal perfusion, filtration, and oxygenation after cardiac surgery: a randomized study on crystalloid vs colloid

Neurological biomarkers in the perioperative period

Increase in endogenous erythropoietin synthesis through the normobaric oxygen paradox in cardiac surgery patients Y. Ciccarella, C. Balestra, J. Valsamis,

Molecular weight of hydroxyethyl starch: is there an effect on blood coagulation and pharmacokinetics?‡ C. Madjdpour, N. Dettori, P. Frascarolo, M.

Fibrinogen concentrate substitution therapy in patients with massive haemorrhage and low plasma fibrinogen concentrations C. Fenger-Eriksen, M. Lindberg-Larsen,

Human cerebral microcirculation and oxygen saturation during propofol-induced reduction of bispectral index† K.U. Klein, K. Fukui, P. Schramm, A. Stadie,

ICU fire evacuation preparedness in London: a cross-sectional study

G. Haller, D.S. Courvoisier, H. Anderson, P.S. Myles

J. Carlisle, M. Swart, E.J.C. Dawe, M. Chadwick

Efficacy of aminocaproic, tranexamic acids in the control of bleeding during total knee replacement: a randomized clinical trial Camarasa M.A. , Ollé.

Regional anaesthesia to improve pain outcomes in paediatric surgical patients: a qualitative systematic review of randomized controlled trials S. Suresh,

Controlled hypotension for middle ear surgery: a comparison between remifentanil and magnesium sulphate† J.-H. Ryu, I.-S. Sohn, S.-H. Do British Journal.

Remote measurement of the leak around the uncuffed tracheal tube: objective measurement and physical characteristics A.J. Sims, K. Keltie, C.A. Reay,

C.M. Chalmers, A.M. Bal British Journal of Anaesthesia

K. Ruetzler, G. Grubhofer, W. Schmid, D. Papp, S. Nabecker, D

Estimation of lean body mass in children

Presentation transcript:

Resuscitation with hydroxyethyl starch improves renal function and lactate clearance in penetrating trauma in a randomized controlled study: the FIRST trial (Fluids in Resuscitation of Severe Trauma) M.F.M. James, W.L. Michell, I.A. Joubert, A.J. Nicol, P.H. Navsaria, R.S. Gillespie British Journal of Anaesthesia Volume 107, Issue 5, Pages 693-702 (November 2011) DOI: 10.1093/bja/aer229 Copyright © 2011 The Author(s) Terms and Conditions

Fig 1 Study algorithm for the administration of fluids and assessment of resuscitation. *Clinical indications of shock: <estimated blood loss replaced; HR>110 beats min−1; poor peripheral perfusion; poor saturation signal; cold peripheries; metabolic acidosis: pH<7.25. **Fluid choice: Hb<8 g dl−1: PRBCs; if the TEG r-time was >12 min or the α-angle was <30°, FFP was administered. Plt were administered if the platelet count <60 000 or if the MA on the TEG was <40 mm otherwise FIRST fluid was used. British Journal of Anaesthesia 2011 107, 693-702DOI: (10.1093/bja/aer229) Copyright © 2011 The Author(s) Terms and Conditions

Fig 2 Flow diagram of progress through the phases of the study. B-SAL, blunt trauma allocated to the saline group; B-HES, blunt trauma, HES group; P-SAL, penetrating trauma, saline group; P-HES, penetrating trauma, HES group. *Patients were selected for inclusion by the trauma unit front room staff and not by the Trial Team except for eight patients who were referred but excluded as not meeting protocol requirements. No patient declined consent. British Journal of Anaesthesia 2011 107, 693-702DOI: (10.1093/bja/aer229) Copyright © 2011 The Author(s) Terms and Conditions

Fig 3 (a, b and c) Mean plasma lactate concentrations (sd) in the two categories of trauma patients. together with a linear, mixed effect, regression model of change in lactate over time (sem) with baseline adjustment to 5 mmol litre-1. B-SAL, blunt trauma allocated to the saline group; B-HES, blunt trauma, HES group; P-SAL, penetrating trauma, saline group; P-HES, penetrating trauma, HES group. P-HES demonstrated a small but statistically significantly greater lactate clearance than P-SAL (P=0.029). British Journal of Anaesthesia 2011 107, 693-702DOI: (10.1093/bja/aer229) Copyright © 2011 The Author(s) Terms and Conditions