Dana Branzei, Marco Foiani  Cell 

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Template Switching: From Replication Fork Repair to Genome Rearrangements  Dana Branzei, Marco Foiani  Cell  Volume 131, Issue 7, Pages 1228-1230 (December 2007) DOI: 10.1016/j.cell.2007.12.007 Copyright © 2007 Elsevier Inc. Terms and Conditions

Figure 1 Fork Repair and Chromosomal Rearrangements by Template Switching Replication forks encountering DNA lesions (red star) on the template strand can engage the nascent chains into template switching to bypass the DNA lesion. Forks encountering low-copy repeats or repetitive elements are prone to stalling and, occasionally, switch templates in the presence of a nearby template at another fork, thus generating chromosomal rearrangements. This process might require regions of microhomology (red bars). Cell 2007 131, 1228-1230DOI: (10.1016/j.cell.2007.12.007) Copyright © 2007 Elsevier Inc. Terms and Conditions

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