David P. Mason, MD, Jeevanantham Rajeswaran, MS, Sudish C

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Spirometry After Transplantation: How Much Better Are Two Lungs Than One? David P. Mason, MD, Jeevanantham Rajeswaran, MS, Sudish C. Murthy, MD, PhD, Ann M. McNeill, RN, Marie M. Budev, DO, Atul C. Mehta, MD, Gösta B. Pettersson, MD, PhD, Eugene H. Blackstone, MD The Annals of Thoracic Surgery Volume 85, Issue 4, Pages 1193-1201.e2 (April 2008) DOI: 10.1016/j.athoracsur.2007.12.023 Copyright © 2008 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Spirometry after lung transplantation. Solid lines represent parametric estimates of the mean spirometry values across time and are enclosed within 68% bootstrapped percentile confidence intervals (clashed lines). Solid circles are actual grouped data, without regard to repeated measurements, used as a crude verification of the model. (A) Forced expiratory volume in 1 second (FEV1, % of predicted). (B) Forced vital capacity (FVC, % of predicted). The Annals of Thoracic Surgery 2008 85, 1193-1201.e2DOI: (10.1016/j.athoracsur.2007.12.023) Copyright © 2008 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Spirometry after single-lung (lower lines) and double-lung (top lines) transplantation (LTx). Format is as in Fig 1. Symbols are actual grouped data without regard to repeated measurements, used as a crude verification of the model. (Open circles = double LTx; diamonds = single LTx.) (A) Forced expiratory volume in 1 second (FEV1, % of predicted). (B) Forced vital capacity (FVC, % of predicted). The Annals of Thoracic Surgery 2008 85, 1193-1201.e2DOI: (10.1016/j.athoracsur.2007.12.023) Copyright © 2008 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Predicted mean spirometry values according to single lung vs double lung transplantation (LTx) and indication for transplant. (α-1 = α-1 antitrypsin deficiency; Bronch = bronchiectasis; CF = cystic fibrosis; COPD = chronic obstructive pulmonary disease; Eisen = Eisenmenger syndrome; IPF = idiopathic pulmonary fibrosis; PPH = primary pulmonary hypertension. (A) Forced expiratory volume in 1 second (FEV1, % of predicted). (B) Forced vital capacity (FVC, % of predicted). The Annals of Thoracic Surgery 2008 85, 1193-1201.e2DOI: (10.1016/j.athoracsur.2007.12.023) Copyright © 2008 The Society of Thoracic Surgeons Terms and Conditions

Appendix Fig 1 Number of patients with spirometry measurements available at and beyond various time points, and number of spirometry measurements available for analysis. (Black bars = patients; grey bars = spirometry measurements.) (A) All patients. (B) Double-lung transplant patients. (C) Single lung transplant patients. The Annals of Thoracic Surgery 2008 85, 1193-1201.e2DOI: (10.1016/j.athoracsur.2007.12.023) Copyright © 2008 The Society of Thoracic Surgeons Terms and Conditions

Appendix Fig 1 Number of patients with spirometry measurements available at and beyond various time points, and number of spirometry measurements available for analysis. (Black bars = patients; grey bars = spirometry measurements.) (A) All patients. (B) Double-lung transplant patients. (C) Single lung transplant patients. The Annals of Thoracic Surgery 2008 85, 1193-1201.e2DOI: (10.1016/j.athoracsur.2007.12.023) Copyright © 2008 The Society of Thoracic Surgeons Terms and Conditions