Relationship Between Characteristics of Medications and Drug-Induced Liver Disease Phenotype and Outcome  Raj Vuppalanchi, Raghavender Gotur, K. Rajender Reddy, Robert J. Fontana, Marwan Ghabril, Andrzej S. Kosinski, Jiezhun Gu, Jose Serrano, Naga Chalasani  Clinical Gastroenterology and Hepatology  Volume 12, Issue 9, Pages 1550-1555 (September 2014) DOI: 10.1016/j.cgh.2013.12.016 Copyright © 2014 AGA Institute Terms and Conditions

Figure 1 Flowchart describing selection of study population. A total of 1083 subjects with DILI were enrolled up to March 2012. Among these, 631 subjects had DILI from a single drug. After causality adjudication, there were 412 subjects with adjudication status of definite, highly likely, and probable (1, 2, or 3). An additional 29 cases were excluded because of unknown dosage, drug start/stop date, or mode of administration. The final study cohort consisted of 383 DILI cases resulting from 107 different drugs that satisfied the study inclusion criteria: (1) DILI occurring from a single agent, (2) administered orally, (3) known daily dosage, and (4) causality of 1, 2, or 3. Clinical Gastroenterology and Hepatology 2014 12, 1550-1555DOI: (10.1016/j.cgh.2013.12.016) Copyright © 2014 AGA Institute Terms and Conditions