Low-dose Aspirin and Cancer Mortality: A Meta-analysis of Randomized Trials Edward J. Mills, PhD, MSc, Ping Wu, MD, MSc, Mark Alberton, BSc, Steve Kanters,

Slides:

Advertisements

Similar presentations

Low-Dose Aspirin in Patients with Stable Cardiovascular Disease: A Meta-analysis Jeffrey S. Berger, MD, MS, David L. Brown, MD, Richard C. Becker, MD The.

Advertisements

Date of download: 6/21/2016 From: Aspirin for the Primary Prevention of Cardiovascular Events: A Systematic Evidence Review for the U.S. Preventive Services.

Date of download: 6/21/2016 Copyright © The American College of Cardiology. All rights reserved. From: Aspirin Therapy in Primary Cardiovascular Disease.

Date of download: 6/26/2016 From: Aspirin for the Prevention of Cancer Incidence and Mortality: Systematic Evidence Reviews for the U.S. Preventive Services.

Date of download: 7/10/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Choice of Antithrombotic Therapy for Stroke Prevention.

Volume 370, Issue 9586, Pages (August 2007)

Low-Dose Aspirin for Primary Prevention of Cardiovascular Events in Patients With Diabetes: A Meta-Analysis Stavros Stavrakis, MD The American Journal.

Overweight and obesity as risk factors for atrial fibrillation or flutter: The Danish Diet, Cancer, and Health Study Lars Frost, MD, PhD, Lone Juul Hune,

From: Adjusted-Dose Warfarin versus Aspirin for Preventing Stroke in Patients with Atrial Fibrillation Ann Intern Med. 2007;147(8): doi: /

Paul D. Stein, MD, Fadi Matta, MD, Mary J. Hughes, DO

New-onset Atrial Fibrillation Predicts Heart Failure Progression

Aspirin Use Among U.S. Adults

Alfred A. Bartolucci, PhD, Michal Tendera, MD, George Howard, DrPH

Long-term Low-Molecular-Weight Heparin versus Usual Care in Proximal-Vein Thrombosis Patients with Cancer Russell D. Hull, MBBS, MSc, Graham F. Pineo,

Role of the CHADS2 Score in Acute Coronary Syndromes

Renato D. Lopes, MD, PhD, Li Li, MS, Christopher B

Dabigatran and Warfarin for Secondary Prevention of Stroke in Atrial Fibrillation Patients: A Nationwide Cohort Study Torben Bjerregaard Larsen, MD,

Alternative Smoking Cessation Aids: A Meta-analysis of Randomized Controlled Trials Mehdi Tahiri, MD, Salvatore Mottillo, MD, Lawrence Joseph, PhD, Louise.

Duration of Dual Antiplatelet Therapy in Patients with an Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention Chirag Bavishi, MD, MPH,

Impact of More Restrictive Blood Transfusion Strategies on Clinical Outcomes: A Meta- analysis and Systematic Review Shelley R. Salpeter, MD, Jacob S.

Dabigatran and Warfarin for Secondary Prevention of Stroke in Atrial Fibrillation Patients: A Nationwide Cohort Study Torben Bjerregaard Larsen, MD,

Alexander A. Leung, MD, MPH, Finlay A. McAlister, MD, MSc, Samuel R. G

Alternative Smoking Cessation Aids: A Meta-analysis of Randomized Controlled Trials Mehdi Tahiri, MD, Salvatore Mottillo, MD, Lawrence Joseph, PhD, Louise.

Prevalence, Predictors, and Outcomes in Treatment-resistant Hypertension in Patients with Coronary Disease Sripal Bangalore, MD, MHA, Rana Fayyad, PhD,

Samy Suissa, PhD, Abbas Kezouh, PhD, Pierre Ernst, MD, MSc

Systematic Review of the Mediterranean Diet for Long-Term Weight Loss

Systematic Review and Meta-analysis of Adverse Events of Low-dose Aspirin and Clopidogrel in Randomized Controlled Trials Kenneth R. McQuaid, MD, Loren.

Overweight and obesity as risk factors for atrial fibrillation or flutter: The Danish Diet, Cancer, and Health Study Lars Frost, MD, PhD, Lone Juul Hune,

CHA2DS2-VASc Score Is Directly Associated with the Risk of Pulmonary Embolism in Patients with Atrial Fibrillation Walid Saliba, MD, MPH, Gad Rennert,

Net Clinical Benefit of Non-vitamin K Antagonist Oral Anticoagulants Versus Warfarin in Phase III Atrial Fibrillation Trials Giulia Renda, MD, PhD, Marta.

Efficacy and Safety of Non-Vitamin K Antagonist Oral Anticoagulants After Cardioversion for Nonvalvular Atrial Fibrillation Giulia Renda, MD, PhD, Marco.

Effect of Aspirin on Mortality in the Primary Prevention of Cardiovascular Disease Nina Raju, MD, MsC, Magdalena Sobieraj-Teague, MBBS, Jack Hirsh, MD,

Trend in Mortality after Stroke with Atrial Fibrillation

Use of Targeted Temperature Management After Out-of-hospital Cardiac Arrest: A Meta- Analysis of Randomized Controlled Trials Ahmed Mahmoud, MD, Islam.

Marc Carrier, MD, MSc, Alok A

Long-term Low-Molecular-Weight Heparin versus Usual Care in Proximal-Vein Thrombosis Patients with Cancer Russell D. Hull, MBBS, MSc, Graham F. Pineo,

Cardiovascular Disease and CKD: Core Curriculum 2010

All-cause Mortality Associated with TNF-α Inhibitors in Rheumatoid Arthritis: A Meta- Analysis of Randomized Controlled Trials Lucile Poiroux, MD, Yannick.

Gregory Y.H. Lip, MD, Jonathan L. Halperin, MD, Hung-Fat Tse, MD, PhD

Richard C. Cook, MD, MS, Michael H

Triple vs Dual Antithrombotic Therapy in Patients with Atrial Fibrillation and Coronary Artery Disease Renato D. Lopes, MD, MHS, PhD, Meena Rao, MD,

CHADS2 Score, Statin Therapy, and Risks of Atrial Fibrillation

TIA for the Internist The American Journal of Medicine

Hong-Tao Tie, MD, Rui Shi, MD The American Journal of Medicine

History of Thyroid Disorders in Relation to Clinical Outcomes in Atrial Fibrillation Helene Bruere, MD, Laurent Fauchier, MD, PhD, Anne Bernard Brunet,

Cardiovascular Risks of Exogenous Testosterone Use Among Men: A Systematic Review and Meta-Analysis G. Caleb Alexander, MD, MS, Geetha Iyer, MBBS, Eleanor.

Evaluation of the HAS-BLED, ATRIA, and ORBIT Bleeding Risk Scores in Patients with Atrial Fibrillation Taking Warfarin Keitaro Senoo, MD, Marco Proietti,

Interaction of Physical Activity and Body Mass Index on Mortality in Coronary Heart Disease: Data from the Nord-Trøndelag Health Study Trine Moholdt,

When Guidelines Cause Hypertension

Isla M. Ogilvie, PhD, Nick Newton, PhD, Sharon A

Yousef Rezaei, MD American Journal of Kidney Diseases

Scope of Problem of Pulmonary Arterial Hypertension

Clinical Outcomes After Treatment of Cocaine-Induced Chest Pain with Beta-Blockers: A Systematic Review and Meta-Analysis Kevin Bryan Lo, MD, Hafeez.

Usefulness of CHADS2 and CHA2DS2-VASc Scores in the Prediction of New-Onset Atrial Fibrillation: A Population-Based Study Walid Saliba, MD, MPH, Naomi.

MATCH Results: Implications for the Internist

Canadian Cardiovascular Society Atrial Fibrillation Guidelines 2010: Prevention of Stroke and Systemic Thromboembolism in Atrial Fibrillation and Flutter

Insomnia in the Elderly: Cause, Approach, and Treatment

To Reduce Stroke with PFO Closure, Respect the Shunt

Effect of Folic Acid, with or without Other B Vitamins, on Cognitive Decline: Meta- Analysis of Randomized Trials David S. Wald, MA, MRCP, MD, Anuradhani.

Long-term Effect of Chronic Oral Anticoagulation with Warfarin after Acute Myocardial Infarction Salman A. Haq, MD, John F. Heitner, MD, Terrence J.

One-way Versus Two-way Text Messaging on Improving Medication Adherence: Meta- analysis of Randomized Trials David S. Wald, MD, FRCP, Shahena Butt, MSc,

National Trends in Ambulatory Oral Anticoagulant Use

KDOQI Clinical Practice Guideline and Clinical Practice Recommendations for Anemia in Chronic Kidney Disease: 2007 Update of Hemoglobin Target American.

Combining Antiplatelet and Antithrombotic Therapy (Triple Therapy): What Are the Risks and Benefits? Luis Alejandro Asencio, MD, Jennifer J. Huang, DO,

Is Salt a Culprit or an Innocent Bystander in Hypertension

Meta-analysis of randomized trials on the efficacy of posterior pericardiotomy in preventing atrial fibrillation after coronary artery bypass surgery

Efficacy and Safety of Non-Vitamin K Antagonist Oral Anticoagulants After Cardioversion for Nonvalvular Atrial Fibrillation Giulia Renda, MD, PhD, Marco.

Falls in Older Adults: Risk Assessment, Management and Prevention

Gentamicin collagen sponges for the prevention of sternal wound infection: A meta- analysis of randomized controlled trials Michael N. Mavros, MD, Pantelis.

Meta-analysis of trials examining the effects of aspirin on risk of CVD events in patients with diabetes. Meta-analysis of trials examining the effects.

Presentation transcript:

Low-dose Aspirin and Cancer Mortality: A Meta-analysis of Randomized Trials Edward J. Mills, PhD, MSc, Ping Wu, MD, MSc, Mark Alberton, BSc, Steve Kanters, MSc, Angel Lanas, MD, DSc, Richard Lester, MD The American Journal of Medicine Volume 125, Issue 6, Pages 560-567 (June 2012) DOI: 10.1016/j.amjmed.2012.01.017 Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 1 Flow diagram of included studies. RCT = randomized clinical trial; CVD = cardiovascular disease. The American Journal of Medicine 2012 125, 560-567DOI: (10.1016/j.amjmed.2012.01.017) Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 2 Nonvascular mortality. Forest plot displays the individual relative risk point estimates with 95% CI and the pooled overall relative risk estimate. UK-TIA = United Kingdom Transient Ischemic Attack; PHS = Physicians' Health Study; ECLAP = European Collaboration on Low-dose Aspirin in Polycythemia Vera; TPT = Thrombosis Prevention Trial; SPAF = Stroke Prevention in Atrial Fibrillation; CLIPS = Critical Leg Ischaemia Prevention Study; HOT = Hypertension Optimal Treatment; PEP = Pulmonary Embolism Prevention; FFAACS = Fluindione, Fibrillation Auriculaire, Aspirin et Contraste Spontane; SALT = Swedish Aspirin Low-Dose Trial; PPP = Primary Prevention Project; POPADAD = Prevention Of Progression of Arterial Disease And Diabetes; AFASAK = The Atrial Fibrillation, Aspirin and Anticoagulant Therapy Study; SAPAT = Swedish Angina Pectoris Aspirin Trial; EAFT = European Atrial Fibrillation Trial. The American Journal of Medicine 2012 125, 560-567DOI: (10.1016/j.amjmed.2012.01.017) Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 3 Cancer mortality. Forest plot shows the individual relative risk point estimates with 95% CI and the pooled overall relative risk estimate. UK-TIA = United Kingdom Transient Ischemic Attack; TPT = Thrombosis Prevention Trial; CLIPS = Critical Leg Ischaemia Prevention Study; FFAACS = Fluindione, Fibrillation Auriculaire, Aspirin et Contraste Spontane; SALT = Swedish Aspirin Low-Dose Trial; POPADAD = Prevention Of Progression of Arterial Disease And Diabetes; SAPAT = Swedish Angina Pectoris Aspirin Trial. The American Journal of Medicine 2012 125, 560-567DOI: (10.1016/j.amjmed.2012.01.017) Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 4 Cumulative effects of aspirin on cancer mortality. Cumulative Forest plot shows the individual relative risk point estimates with 95% CI according to shortest to longest duration of trials reporting cancer mortality. FFAACS = Fluindione, Fibrillation Auriculaire, Aspirin et Contraste Spontane; CLIPS = Critical Leg Ischaemia Prevention Study; SALT = Swedish Aspirin Low-Dose Trial; TPT = Thrombosis Prevention Trial; UK-TIA = United Kingdom Transient Ischemic Attack; SAPAT = Swedish Angina Pectoris Aspirin Trial; POPADAD = Prevention Of Progression of Arterial Disease And Diabetes. The American Journal of Medicine 2012 125, 560-567DOI: (10.1016/j.amjmed.2012.01.017) Copyright © 2012 Elsevier Inc. Terms and Conditions