Andrzej T. Slominski, MD, PhD Mayo Clinic Proceedings

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Melanoma Resistance: A Bright Future for Academicians and a Challenge for Patient Advocates Andrzej T. Slominski, MD, PhD Mayo Clinic Proceedings Volume 89, Issue 4, Pages 429-433 (April 2014) DOI: 10.1016/j.mayocp.2014.02.009 Copyright © 2014 Mayo Foundation for Medical Education and Research Terms and Conditions

Figure Current approaches to treating metastatic melanoma resemble “Sisyphus work” from Greek mythology. Similar to Sisyphus, it will be problematic to reach the pinnacle where targeted cure is achieved because clonal heterogeneity will overcome the drug effects in most patients with metastatic melanoma. BRAF = proto-oncogene B-Raf; MEK1/2 = mitogen-activated protein kinase kinase 1 or 2; N-RAS = neuroblastoma RAS viral oncogene homolog; PDGFRB = beta-type platelet-derived growth factor; PI3K = phosphatidylinositide 3-kinase; PTEN = phosphatase and tensin homolog. Mayo Clinic Proceedings 2014 89, 429-433DOI: (10.1016/j.mayocp.2014.02.009) Copyright © 2014 Mayo Foundation for Medical Education and Research Terms and Conditions