Volume 15, Issue 8, Pages R282-R283 (April 2005) Autophagy  Daniel J. Klionsky  Current Biology  Volume 15, Issue 8, Pages R282-R283 (April 2005) DOI: 10.1016/j.cub.2005.04.013 Copyright © 2005 Elsevier Ltd Terms and Conditions

Figure 1 The process of macroautophagy. A double-membrane-bound autophagosome sequesters cytoplasm. Fusion with the lysosome or vacuole releases the single-membrane autophagic body (AB) that is broken down, allowing degradation of the cargo and recycling of the resulting macromolecules. In yeast, most of the Atg proteins localize to the pre-autophagosomal structure (PAS), which may be the site of nucleation for the sequestering vesicle. Current Biology 2005 15, R282-R283DOI: (10.1016/j.cub.2005.04.013) Copyright © 2005 Elsevier Ltd Terms and Conditions