Cécile L. Maire, Keith L. Ligon Cancer Cell

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Presentation transcript:

Glioma Models: New GEMMs Add “Class” with Genomic and Expression Correlations Cécile L. Maire, Keith L. Ligon Cancer Cell Volume 19, Issue 3, Pages 295-297 (March 2011) DOI: 10.1016/j.ccr.2011.02.018 Copyright © 2011 Elsevier Inc. Terms and Conditions

Figure 1 Combinatorial Tumor Suppressor Loss in Mouse Glioma Models Reveals Novel Correlations to Human Glioma Drivers and Expression Subclasses (A) Schematic describing conditional and inducible deletion of p53, Pten, and Rb1 in Gfap-positive adult brain astrocytes and stem cells and subsequent comparative genomic correlations with human GBM datasets. (B) Summary of specific combinations of suppressor deletion reveal hidden secondary genetic and subclass differences in adult murine high-grade gliomas. Cancer Cell 2011 19, 295-297DOI: (10.1016/j.ccr.2011.02.018) Copyright © 2011 Elsevier Inc. Terms and Conditions