Xenobiotic receptor meets NF-κB, a collision in the small bowel

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Xenobiotic receptor meets NF-κB, a collision in the small bowel Wen Xie, Yanan Tian Cell Metabolism Volume 4, Issue 3, Pages 177-178 (September 2006) DOI: 10.1016/j.cmet.2006.08.004 Copyright © 2006 Elsevier Inc. Terms and Conditions

Figure 1 Mutual repression between PXR/SXR and NF-κB signaling pathways The PXR/SXR and NF-κB mutual suppression may link xenobiotic metabolism and inflammation in the hepatointestinal axis. IBD, inflammatory bowel disease; ICAM, intercellular adhesion molecule; LPS, lipopolysaccharide; NF-κB, nuclear factor kappa B; PXR, pregnane X receptor; PXRE, PXR response element; SXR, steroid and xenobiotic receptor; TNF, tumor necrosis factor. Cell Metabolism 2006 4, 177-178DOI: (10.1016/j.cmet.2006.08.004) Copyright © 2006 Elsevier Inc. Terms and Conditions