Christophe Sirac, Frank Bridoux Kidney International

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Mesangial cells as amyloid factory: a unique contribution of animal models Christophe Sirac, Frank Bridoux Kidney International Volume 86, Issue 4, Pages 669-671 (October 2014) DOI: 10.1038/ki.2014.182 Copyright © 2014 International Society of Nephrology Terms and Conditions

Figure 1 Principal features of monoclonal immunoglobulin light chain-related renal disorders, with contribution of experimental models (red). V domain involvement is now demonstrated in all monoclonal light chain (LC)-related renal pathologies, but specific peculiarities including LC isotypes, germline V domains, somatic mutations, and cellular responses to LC toxicity distinguish the various diseases. LCDD, LC deposition disease; MGUS, monoclonal gammopathy of undetermined significance; MM, multiple myeloma. Kidney International 2014 86, 669-671DOI: (10.1038/ki.2014.182) Copyright © 2014 International Society of Nephrology Terms and Conditions