Shedding of the endothelial glycocalyx during cardiac surgery: On-pump versus off- pump coronary artery bypass graft surgery Dirk Bruegger, MD, Markus.

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Presentation transcript:

Shedding of the endothelial glycocalyx during cardiac surgery: On-pump versus off- pump coronary artery bypass graft surgery Dirk Bruegger, MD, Markus Rehm, MD, Jan Abicht, MD, Joern Oliver Paul, MD, Mechthild Stoeckelhuber, MD, PhD, Markus Pfirrmann, MSc, Bruno Reichart, MD, Bernhard F. Becker, MD, PhD, Frank Christ, MD The Journal of Thoracic and Cardiovascular Surgery Volume 138, Issue 6, Pages 1445-1447 (December 2009) DOI: 10.1016/j.jtcvs.2008.07.063 Copyright © 2009 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Individual and median values of syndecan-1 and heparan sulfate (upper and bottom panels, respectively) in arterial blood plasma of patients undergoing conventional coronary artery bypass grafting (CCAB; left panels) and patients undergoing off-pump coronary artery bypass grafting (OPCAB; right panels) at different operative stages. Time points are as defined in the text. Syndecan-1 was determined directly by using an enzyme-linked immunosorbent assay (Diaclone Research, Besancon, France). Heparan sulfate concentration was measured after pretreatment of plasma with Actinase E (Sigma, St Louis, Mo) with a special enzyme-linked immunosorbent assay kit (Seikagaku Corporation, Tokyo, Japan). ∗P < .05 versus T0 (Wilcoxon signed-rank test; P value was corrected according to the Bonferroni adjustment for testing 5 times). The Journal of Thoracic and Cardiovascular Surgery 2009 138, 1445-1447DOI: (10.1016/j.jtcvs.2008.07.063) Copyright © 2009 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Immunostaining of a human saphenous vein and adventitial artery with monoclonal antibody against heparan sulfate (A) and syndecan-1 (B). Sections (5 μm) were immunohistochemically stained with monoclonal antibodies (heparan sulfate: Seikagaku Corporation, Tokyo, Japan; syndecan-1: Biosource International, Camarillo, Calif). (Original magnification: A, 2×; B, 40×. HS, Heparan sulfate; VL, vascular lumen; S, syndecan-1. The Journal of Thoracic and Cardiovascular Surgery 2009 138, 1445-1447DOI: (10.1016/j.jtcvs.2008.07.063) Copyright © 2009 The American Association for Thoracic Surgery Terms and Conditions