Bay induced aggregation of Cp occurs in HBV-infected HepG2-NTCP cells.

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Bay induces aberrant assembly of Cp

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Bay 38-7690-induced aggregation of Cp occurs in HBV-infected HepG2-NTCP cells. Bay 38-7690-induced aggregation of Cp occurs in HBV-infected HepG2-NTCP cells. (A) HepG2-NTCP cells were infected with HBV, treated with DMSO or 5 µM Bay 38-7690, cultured for 4 days, and stained for Cp. Bars, 20 µm. (B) Cp fluorescence was quantified and plotted as a nuclear-to-cytoplasmic ratio. The values represent mean ± standard error of the mean from at least two independent experiments; 9 images per treatment per experiment were analyzed. Statistical analysis was conducted with a two-tailed unpaired t test. Andrew D. Huber et al. mSphere 2018; doi:10.1128/mSphereDirect.00131-18