Pediatric Eosinophilic Esophagitis Symptom Scores (PEESS v2

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Presentation transcript:

Pediatric Eosinophilic Esophagitis Symptom Scores (PEESS v2 Pediatric Eosinophilic Esophagitis Symptom Scores (PEESS v2.0) identify histologic and molecular correlates of the key clinical features of disease Lisa J. Martin, PhD, James P. Franciosi, MD, MS, MSCE, Margaret H. Collins, MD, J. Pablo Abonia, MD, James J. Lee, PhD, Kevin A. Hommel, PhD, James W. Varni, PhD, J. Tommie Grotjan, BS, Michael Eby, BS, Hua He, MS, Keith Marsolo, PhD, Philip E. Putnam, MD, Jose M. Garza, MD, Ajay Kaul, MD, Ting Wen, PhD, Marc E. Rothenberg, MD, PhD Journal of Allergy and Clinical Immunology Volume 135, Issue 6, Pages 1519-1528.e8 (June 2015) DOI: 10.1016/j.jaci.2015.03.004 Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Relationships between gastrointestinal symptoms and PEESS v2.0 scores. The x-axis represents the negative log10 P value of the Wilcoxon rank sum test comparing subjects reporting the clinical symptom with those who do not report the clinical symptom. The x-axis columns in the figure are PEESS v2.0 scores, whereas the y-axis indicates clinical symptoms reported as yes/no. GI, Gastrointestinal; NV, nausea/vomiting domain. Journal of Allergy and Clinical Immunology 2015 135, 1519-1528.e8DOI: (10.1016/j.jaci.2015.03.004) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Spearman correlations between PEESS v2.0 scores and disease parameters. The strength of the association with a diagnostic subset of the EoE transcriptome is measured by using Spearman ρ (text within cell). Darker red shades indicate stronger negative correlations, whereas darker blue shades indicate stronger positive correlations. Boldface values indicate correlations that are significant at a P value of .05 or less. Eos, Eosinophil; NV, nausea/vomiting domain. Journal of Allergy and Clinical Immunology 2015 135, 1519-1528.e8DOI: (10.1016/j.jaci.2015.03.004) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Spearman correlations between PEESS v2.0 scores and a diagnostic subset of the EoE transcriptome. Darker red shades indicate stronger negative correlations, whereas darker blue shades indicate stronger positive correlations. Correlations are by functional groupings of genes. NV, Nausea/vomiting domain. Journal of Allergy and Clinical Immunology 2015 135, 1519-1528.e8DOI: (10.1016/j.jaci.2015.03.004) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 Hierarchic relationships between domains based on gene expression profile correlations. Using Spearman r for the correlation between the EDP gene expression and PEESS v2.0 domain scores, we created a clustering tree representing the hierarchic order of the domain's representativeness and plotted it with the Spearman r–based heat diagram for the correlation at gene level. Darker red shades indicate stronger negative correlations, whereas darker blue shades indicate stronger positive correlations. The shorter the distance (tree-branch length), the more similar the expression correlation for each domain. NV, Nausea/vomiting domain. Journal of Allergy and Clinical Immunology 2015 135, 1519-1528.e8DOI: (10.1016/j.jaci.2015.03.004) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 5 Associations between the PEESS v2.0 dysphagia domain and a diagnostic subset of the EoE transcriptome. The x-axis represents the negative log10 P value of the Spearman correlation between the dysphagia domain and a diagnostic subset of genes from the EoE transcriptome (EDP). The y-axis is organized by genes within functional groupings; color shading is for ease of interpretation only. The dashed line indicates a P value of .05. Journal of Allergy and Clinical Immunology 2015 135, 1519-1528.e8DOI: (10.1016/j.jaci.2015.03.004) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Median correlation (and upper 75% quartile) between eosinophil measures (eosinophil count and EPX staining) and PEESS v2.0 scores demonstrates specific association with the dysphagia domain. Black bars represent the distal esophagus, and gray bars represent the proximal esophagus. The median dysphagia domain is statistically higher than the total and domain scores for both the proximal and distal esophagus (P ≤ .0049 for all except distal pain [P = .022]). Journal of Allergy and Clinical Immunology 2015 135, 1519-1528.e8DOI: (10.1016/j.jaci.2015.03.004) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions