Liquids, Fibers, and Gels: The Many Phases of Neurodegeneration

Slides:

Advertisements

Similar presentations

Drosophila SPARC Is a Self-Protective Signal Expressed by Loser Cells during Cell Competition Marta Portela, Sergio Casas-Tinto, Christa Rhiner, Jesús.

Advertisements

Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell Copyright.

The TEAD/TEF Family of Transcription Factor Scalloped Mediates Hippo Signaling in Organ Size Control Lei Zhang, Fangfang Ren, Qing Zhang, Yongbin Chen,

Bleach Activates a Redox-Regulated Chaperone by Oxidative Protein Unfolding J. Winter, M. Ilbert, P.C.F. Graf, D. Özcelik, U. Jakob Cell Volume 135, Issue.

Binocular rivalry Colin W.G. Clifford Current Biology Volume 19, Issue 22, Pages R1022-R1023 (December 2009) DOI: /j.cub Copyright ©

What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages (January 2014) DOI: /j.cell

Fatty Acid Trafficking in Starved Cells: Regulation by Lipid Droplet Lipolysis, Autophagy, and Mitochondrial Fusion Dynamics Angelika S. Rambold, Sarah.

Snail1 Is a Transcriptional Effector of FGFR3 Signaling during Chondrogenesis and Achondroplasias Cristina A. de Frutos, Sonia Vega, Miguel Manzanares,

Mitotic Spindle Orientation in Asymmetric and Symmetric Cell Divisions during Animal Development Xavier Morin, Yohanns Bellaïche Developmental Cell Volume.

Maintaining Cell Identity through Global Control of Genomic Organization Gioacchino Natoli Immunity Volume 33, Issue 1, Pages (July 2010) DOI: /j.immuni

Preference Distributions of Primary Motor Cortex Neurons Reflect Control Solutions Optimized for Limb Biomechanics Timothy P. Lillicrap, Stephen H. Scott.

Making Proteins in the Powerhouse B. Martin Hällberg, Nils-Göran Larsson Cell Metabolism Volume 20, Issue 2, Pages (August 2014) DOI: /j.cmet

UvrD Helicase Unwinds DNA One Base Pair at a Time by a Two-Part Power Stroke Jae Young Lee, Wei Yang Cell Volume 127, Issue 7, Pages (December.

Cost of Unneeded Proteins in E. coli Is Reduced after Several Generations in Exponential Growth Irit Shachrai, Alon Zaslaver, Uri Alon, Erez Dekel Molecular.

Eph-Ephrin Bidirectional Signaling in Physiology and Disease Elena B. Pasquale Cell Volume 133, Issue 1, Pages (April 2008) DOI: /j.cell

Hemogenic Endothelial Cell Specification Requires c-Kit, Notch Signaling, and p27- Mediated Cell-Cycle Control Kathrina L. Marcelo, Tiffany M. Sills, Suleyman.

Functional Analysis of the Neurofibromatosis Type 2 Protein by Means of Disease- Causing Point Mutations Renee P. Stokowski, David R. Cox The American.

Evidence for a Myotomal Hox/Myf Cascade Governing Nonautonomous Control of Rib Specification within Global Vertebral Domains Tânia Vinagre, Natalia Moncaut,

Extracellular Matrix Protein Anosmin Promotes Neural Crest Formation and Regulates FGF, BMP, and WNT Activities Yukinori Endo, Hiroko Ishiwata-Endo, Kenneth.

ER-to-Plasma Membrane Tethering Proteins Regulate Cell Signaling and ER Morphology Andrew G. Manford, Christopher J. Stefan, Helen L. Yuan, Jason A. MacGurn,

Neuronal Cell Types and Connectivity: Lessons from the Retina H. Sebastian Seung, Uygar Sümbül Neuron Volume 83, Issue 6, Pages (September 2014)

Evolution of the Cancer Stem Cell Model Antonija Kreso, John E. Dick Cell Stem Cell Volume 14, Issue 3, Pages (March 2014) DOI: /j.stem

Nuclear Receptors, RXR, and the Big Bang Ronald M. Evans, David J. Mangelsdorf Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell

IPSC Crowdsourcing: A Model for Obtaining Large Panels of Stem Cell Lines for Screening Mahendra Rao Cell Stem Cell Volume 13, Issue 4, Pages (October.

Human Brown Adipose Tissue Sven Enerbäck Cell Metabolism Volume 11, Issue 4, Pages (April 2010) DOI: /j.cmet Copyright © 2010.

The Good Fat Cell Volume 147, Issue 7, (December 2011) DOI: /j.cell Copyright © 2011 Terms and Conditions Terms and Conditions.

Keap1/Nrf2 Signaling Regulates Oxidative Stress Tolerance and Lifespan in Drosophila Gerasimos P. Sykiotis, Dirk Bohmann Developmental Cell Volume 14,

The Metabolic Basis of Pulmonary Arterial Hypertension Gopinath Sutendra, Evangelos D. Michelakis Cell Metabolism Volume 19, Issue 4, Pages (April.

Molecular Motors in Neurons: Transport Mechanisms and Roles in Brain Function, Development, and Disease Nobutaka Hirokawa, Shinsuke Niwa, Yosuke Tanaka.

A Hydrodynamic Model for Hindered Diffusion of Proteins and Micelles in Hydrogels Ronald J. Phillips Biophysical Journal Volume 79, Issue 6, Pages

Competition between Blown Fuse and WASP for WIP Binding Regulates the Dynamics of WASP-Dependent Actin Polymerization In Vivo Peng Jin, Rui Duan, Fengbao.

Independent Genomic Control of Neuronal Number across Retinal Cell Types Patrick W. Keeley, Irene E. Whitney, Nils R. Madsen, Ace J. St. John, Sarra Borhanian,

Fate Restriction and Multipotency in Retinal Stem Cells Lázaro Centanin, Burkhard Hoeckendorf, Joachim Wittbrodt Cell Stem Cell Volume 9, Issue 6, Pages.

CDK Inhibitors: Cell Cycle Regulators and Beyond Arnaud Besson, Steven F. Dowdy, James M. Roberts Developmental Cell Volume 14, Issue 2, Pages

Shaping Genetic Alterations in Human Cancer: The p53 Mutation Paradigm Thierry Soussi, Klas G. Wiman Cancer Cell Volume 12, Issue 4, Pages (October.

LC3 Binding to the Scaffolding Protein JIP1 Regulates Processive Dynein-Driven Transport of Autophagosomes Meng-meng Fu, Jeffrey J. Nirschl, Erika L.F.

Cyclin-Dependent Kinases Control Septin Phosphorylation in Candida albicans Hyphal Development Indrajit Sinha, Yan-Ming Wang, Robin Philp, Chang-Run Li,

Gastrulation Movements: the Logic and the Nuts and Bolts Maria Leptin Developmental Cell Volume 8, Issue 3, Pages (March 2005) DOI: /j.devcel

Quantitative Single-Cell Approaches to Stem Cell Research Martin Etzrodt, Max Endele, Timm Schroeder Cell Stem Cell Volume 15, Issue 5, Pages (November.

Sex-Specific Aging in Flies, Worms, and Missing Great-Granddads

Ras Brakes for Hippo Developmental Cell

“TORCing” Neutrophil Chemotaxis

Tolloid gets Sizzled Competing with Chordin

Volume 13, Issue 1, Pages 5-6 (January 2011)

The Evolution of the Algorithms for Collective Behavior

Wt1 Flip-Flops Chromatin in a CTCF Domain

Mother Centrioles Do a Cartwheel to Produce Just One Daughter

MDS Is a Stem Cell Disorder After All

Where Steroids Meet the Cell Cycle in Architecture

Jay Kumar Singh, William E. Balch Developmental Cell

Embryos, Camera, Laser, Action!

Volume 40, Issue 4, Pages (February 2017)

Volume 22, Issue 6, Pages (June 2012)

Volume 13, Issue 1, Pages 5-6 (January 2011)

Gel or Die: Phase Separation as a Survival Strategy

What's so Bor(a)ing about Aurora-A Activation?

Ulrike Harjes, Catherine Verfaillie, Peter Carmeliet

Liquids, Fibers, and Gels: The Many Phases of Neurodegeneration

Modifying Mitochondrial tRNAs: Delivering What the Cell Needs

Getting RNA and Protein in Phase

Mitotic Chromosomes: Not So Silent After All

Volume 143, Issue 6, (December 2010)

Proteins in Plant Brassinosteroid Signaling

Luigi Fontana, Linda Partridge Cell

To Infinium, and Beyond! Cancer Cell

Macrophage Cytoplasmic Transfer in Melanoma Invasion

Nerve Control of Blood Vessel Patterning

Tensins: A New Switch in Cell Migration

PTENtiating CFTR for Antimicrobial Immunity

Ras Brakes for Hippo Developmental Cell

Presentation transcript:

Liquids, Fibers, and Gels: The Many Phases of Neurodegeneration Shana Elbaum-Garfinkle, Clifford P. Brangwynne Developmental Cell Volume 35, Issue 5, Pages 531-532 (December 2015) DOI: 10.1016/j.devcel.2015.11.014 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Model of FUS Protein Assemblies FUS wild-type protein can assemble into liquid or hydrogel states that can be fully reversed to a mixed bulk solution. FUS ALS/FTD mutations lead to assembly of liquids and/or gels that can no longer be reversed, resulting in the retention of additional proteins. This insoluble, irreversible protein phase correlates with deteriorated motor nerve function and decreased lifespan, characteristic of ALS/FTD diseases. Developmental Cell 2015 35, 531-532DOI: (10.1016/j.devcel.2015.11.014) Copyright © 2015 Elsevier Inc. Terms and Conditions