Phagocytes: Fussy about Carbs

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Presentation transcript:

Phagocytes: Fussy about Carbs Ann M. Kerrigan, Gordon D. Brown  Current Biology  Volume 21, Issue 13, Pages R500-R502 (July 2011) DOI: 10.1016/j.cub.2011.05.041 Copyright © 2011 Elsevier Ltd Terms and Conditions

Figure 1 Illustration of the detection of soluble and particulate β-glucans by Dectin-1. (Left) β-glucan-containing particles are recognised by Dectin-1, inducing formation of the phagocytic synapse. CD45 and CD148 phosphatases are excluded from the point of contact allowing initiation of Dectin-1 signalling. (Right) Soluble β-glucans bind to Dectin-1 and induce receptor clustering; however, CD45 and CD148 are not excluded and therefore Dectin-1 signalling is inhibited. (Adapted from [1] with permission from Macmillan Publishers Ltd (Nature).) Current Biology 2011 21, R500-R502DOI: (10.1016/j.cub.2011.05.041) Copyright © 2011 Elsevier Ltd Terms and Conditions