Mitochondrial Matrix Reloaded with RNA

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Mitochondrial Matrix Reloaded with RNA Toshiya Endo, Koji Yamano, Tohru Yoshihisa Cell Volume 142, Issue 3, Pages 362-363 (August 2010) DOI: 10.1016/j.cell.2010.07.024 Copyright © 2010 Elsevier Inc. Terms and Conditions

Figure 1 PNPase Facilitates the Import of RNAs into the Mitochondrial Matrix The polynucleotide phosphorylase (PNPase) precursor is imported into the intermembrane space with the aid of the translocase of outer mitochondrial membrane 40 (TOM40) complex, the translocase of the inner mitochondrial membrane (TIM23) complex, matrix processing peptidase (MPP), and AAA protease Yme1. The trimeric PNPase promotes the import of RNAs from the cytosol into the matrix. Mitochondrial mRNAs are processed in the matrix and their translation products are assembled into the oxidative phosphorylation (OXPHOS) complexes I–IV. The OXA complex integrates proteins from the matrix into the inner membrane. OM, outer membrane; IM, inner membrane. Heat shock protein 70 (Hsp70) is shown as an import motor for presequence-containing proteins. AAC, ADP-ATP carrier. Cell 2010 142, 362-363DOI: (10.1016/j.cell.2010.07.024) Copyright © 2010 Elsevier Inc. Terms and Conditions