Reconstruction of the right ventricular outflow tract with a bovine jugular vein graft fixed with a naturally occurring crosslinking agent (genipin) in.

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Presentation transcript:

Reconstruction of the right ventricular outflow tract with a bovine jugular vein graft fixed with a naturally occurring crosslinking agent (genipin) in a canine model Yen Chang, MDa, Chen-Chi Tsai, PhDb, Huang-Chien Liang, MSc, Hsing-Wen Sung, PhDc The Journal of Thoracic and Cardiovascular Surgery Volume 122, Issue 6, Pages 1208-1218 (December 2001) DOI: 10.1067/mtc.2001.117624 Copyright © 2001 American Association for Thoracic Surgery Terms and Conditions

Fig. 1 Two-dimensional echocardiographic images of the valvular leaflet motion of a genipin-fixed valved conduit obtained at 6 months postoperatively: A, During opening; B, at closure. The Journal of Thoracic and Cardiovascular Surgery 2001 122, 1208-1218DOI: (10.1067/mtc.2001.117624) Copyright © 2001 American Association for Thoracic Surgery Terms and Conditions

Fig. 2 Continuous-wave Doppler velocity spectrum obtained in an implanted genipin-fixed conduit at 6 months postoperatively. The Journal of Thoracic and Cardiovascular Surgery 2001 122, 1208-1218DOI: (10.1067/mtc.2001.117624) Copyright © 2001 American Association for Thoracic Surgery Terms and Conditions

Fig. 3 Photomicrographs of longitudinal sections of the glutaraldehyde- and genipin-fixed valved conduits stained with hematoxylin and eosin and retrieved at 1 month postoperatively: A, Glutaraldehyde-fixed valved conduit; B, genipin-fixed valved conduit. The Journal of Thoracic and Cardiovascular Surgery 2001 122, 1208-1218DOI: (10.1067/mtc.2001.117624) Copyright © 2001 American Association for Thoracic Surgery Terms and Conditions

Fig. 4 Photomicrographs of longitudinal sections of the glutaraldehyde- and genipin-fixed valved conduits stained with hematoxylin and eosin and retrieved at 6 months postoperatively: A, Glutaraldehyde-fixed valved conduit; B, genipin-fixed valved conduit. The Journal of Thoracic and Cardiovascular Surgery 2001 122, 1208-1218DOI: (10.1067/mtc.2001.117624) Copyright © 2001 American Association for Thoracic Surgery Terms and Conditions

Fig. 5 Calcium contents of the glutaraldehyde- and genipin-fixed valvular leaflets before implantation and those retrieved at 1 and 6 months postoperatively. The calcium content of each test sample was determined by using an atomic absorption spectrophotometer and was expressed as micrograms per milligram of dry tissue weight. The Journal of Thoracic and Cardiovascular Surgery 2001 122, 1208-1218DOI: (10.1067/mtc.2001.117624) Copyright © 2001 American Association for Thoracic Surgery Terms and Conditions

Fig. 6 Denaturation temperatures of the glutaraldehyde- and genipin-fixed conduits before implantation and those retrieved at 1 and 6 months postoperatively. The Journal of Thoracic and Cardiovascular Surgery 2001 122, 1208-1218DOI: (10.1067/mtc.2001.117624) Copyright © 2001 American Association for Thoracic Surgery Terms and Conditions

Fig. 7 Tensile-strength values of the glutaraldehyde- and genipin-fixed conduits before implantation and those retrieved at 1 and 6 months postoperatively. The Journal of Thoracic and Cardiovascular Surgery 2001 122, 1208-1218DOI: (10.1067/mtc.2001.117624) Copyright © 2001 American Association for Thoracic Surgery Terms and Conditions

Fig. 8 Schematic illustration of the presumable intramolecular and intermolecular crosslinking structures of the glutaraldehyde-fixed tissue. The Journal of Thoracic and Cardiovascular Surgery 2001 122, 1208-1218DOI: (10.1067/mtc.2001.117624) Copyright © 2001 American Association for Thoracic Surgery Terms and Conditions

Fig. 9 A, Presumable reaction mechanism of amino group with genipin.20,21 B, Schematic illustration of the presumable intramolecular and intermolecular crosslinking structures of the genipin-fixed tissue. The Journal of Thoracic and Cardiovascular Surgery 2001 122, 1208-1218DOI: (10.1067/mtc.2001.117624) Copyright © 2001 American Association for Thoracic Surgery Terms and Conditions