An Uncommon Presentation of Brain Metastases in a Lung Cancer Patient

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An Uncommon Presentation of Brain Metastases in a Lung Cancer Patient Lizza Hendriks, MD, Anne-Marie C. Dingemans, MD, PhD, Martin Lammens, MD, PhD, Monique M. Anten, MD, PhD, Michel M. van den Heuvel, MD, PhD, Linda A. Postma, MD, PhD Journal of Thoracic Oncology Volume 10, Issue 11, Pages 1655-1656 (November 2015) DOI: 10.1097/JTO.0000000000000602 Copyright © 2015 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 1 Brain MRI. Transverse T2-weighted images (A) and transverse (B) and coronal (C) contrast enhanced T1-weighted images show numerous punctiform hyperintense lesions at T2-weighted imaging, with enhancement after administration of gadolinium. The lesions follow a more or less curved pattern, consistent with perivascular distribution, without lesions at the gray-white matter interface. Journal of Thoracic Oncology 2015 10, 1655-1656DOI: (10.1097/JTO.0000000000000602) Copyright © 2015 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 2 Brain autopsy. A and B, Macroscopic aspect of brain tissue show multiple millimetric nodules located along the perivascular spaces; (C) microscopy shows moderately differentiated tubuli with mucin-forming cilindric cells, consistent with adenocarcinoma metastases. Journal of Thoracic Oncology 2015 10, 1655-1656DOI: (10.1097/JTO.0000000000000602) Copyright © 2015 International Association for the Study of Lung Cancer Terms and Conditions