Benjamin D. Humphreys Kidney International Supplements

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Presentation transcript:

Genetic tracing of the epithelial lineage during mammalian kidney repair Benjamin D. Humphreys Kidney International Supplements Volume 1, Issue 3, Pages 83-86 (September 2011) DOI: 10.1038/kisup.2011.19 Copyright © 2011 International Society of Nephrology Terms and Conditions

Figure 1 Lineage tracing to determine origin of epithelial cells after kidney repair. Genetically labeled tubule cells are dark gray, and interstitial cells are unlabeled. After injury, there is necrosis and apoptosis of labeled epithelial cells. If tubule repair involves an interstitial stem cell, these unlabeled cells will dilute the genetic marker and tubules will lose the label after completion of repair (model 1). If surviving epithelial cells are responsible for tubule repair, then the genetic marker will not be diluted by unlabeled cells after completion of repair (model 2). Kidney International Supplements 2011 1, 83-86DOI: (10.1038/kisup.2011.19) Copyright © 2011 International Society of Nephrology Terms and Conditions