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Volume 3, Issue 2, Pages 137-144 (February 2016) Long-term effectiveness and cost-effectiveness of cognitive behavioural therapy as an adjunct to pharmacotherapy for treatment-resistant depression in primary care: follow-up of the CoBalT randomised controlled trial Dr Nicola J Wiles, PhD, Laura Thomas, MPhil, Nicholas Turner, MSc, Kirsty Garfield, MSc, Daphne Kounali, PhD, Prof John Campbell, MD, David Kessler, MD, Prof Willem Kuyken, PhD, Prof Glyn Lewis, PhD, Prof Jill Morrison, PhD, Prof Chris Williams, MD, Prof Tim J Peters, PhD, Sandra Hollinghurst, PhD The Lancet Psychiatry Volume 3, Issue 2, Pages 137-144 (February 2016) DOI: 10.1016/S2215-0366(15)00495-2 Copyright © 2016 Wiles et al. Open Access article distributed under the terms of CC BY Terms and Conditions

Figure 1 CoBalT trial profile extended to include long-term follow-up BDI-II=Beck Depression Inventory score. PHQ-9=Patient Health Questionnaire 9. The Lancet Psychiatry 2016 3, 137-144DOI: (10.1016/S2215-0366(15)00495-2) Copyright © 2016 Wiles et al. Open Access article distributed under the terms of CC BY Terms and Conditions

Figure 2 Mean BDI-II scores for the intervention and usual care groups at 6, 12, and 46 months Error bars represent SD. BDI-II=Beck Depression Inventory score. The Lancet Psychiatry 2016 3, 137-144DOI: (10.1016/S2215-0366(15)00495-2) Copyright © 2016 Wiles et al. Open Access article distributed under the terms of CC BY Terms and Conditions

Figure 3 Cost-effectiveness acceptability curve showing the probability that the intervention is cost effective at different levels of willingness to pay QALY=quality-adjusted life-year. The Lancet Psychiatry 2016 3, 137-144DOI: (10.1016/S2215-0366(15)00495-2) Copyright © 2016 Wiles et al. Open Access article distributed under the terms of CC BY Terms and Conditions