Increased Prevalence of Coronary Artery Disease in Severe Psoriasis and Severe Atopic Dermatitis Kasper Fjellhaugen Hjuler, MD, Morten Böttcher, MD,

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Increased Prevalence of Coronary Artery Disease in Severe Psoriasis and Severe Atopic Dermatitis Kasper Fjellhaugen Hjuler, MD, Morten Böttcher, MD, PhD, Christian Vestergaard, MD, PhD, DMSc, Mette Deleuran, MD, DMSc, Line Raaby, MD, Hans Erik Bøtker, MD, DMSc, Lars Iversen, MD, PhD, Knud Kragballe, MD, PhD, DMSc The American Journal of Medicine Volume 128, Issue 12, Pages 1325-1334.e2 (December 2015) DOI: 10.1016/j.amjmed.2015.05.041 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 48-year-old man with severe psoriasis and calcified coronary lesions on CCTA (left); 57-year-old man with severe lifelong atopic dermatitis and mixed coronary plaque in the LAD on CCTA (middle), and no plaques in the RCA (right). CCTA = cardiac computed tomography angiography; LAD = left anterior descending artery; RCA = right coronary artery. The American Journal of Medicine 2015 128, 1325-1334.e2DOI: (10.1016/j.amjmed.2015.05.041) Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 2 Scatter plot displaying the distribution of coronary artery calcium (CAC) scores in the various groups. The American Journal of Medicine 2015 128, 1325-1334.e2DOI: (10.1016/j.amjmed.2015.05.041) Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 3 Overall segment analysis demonstrating prevalence, subtype, and vessel distribution of segments with atherosclerosis and luminal abnormalities visualized as proportion of all analyzable segments. AD = atopic dermatitis; Cx = circumflex; LAD = left anterior descending artery; LM = left main coronary artery; RCA = right coronary artery. The American Journal of Medicine 2015 128, 1325-1334.e2DOI: (10.1016/j.amjmed.2015.05.041) Copyright © 2015 Elsevier Inc. Terms and Conditions

Supplementary Figure 18-segment model of the coronary tree illustrating the distribution of segments with luminal abnormalities in psoriasis, atopic dermatitis, and controls (percentage of segments with stenosis within group). AD = atopic dermatitis; Con = controls; Cx = circumflex; D1/D2 = diagonal branch; LAD = left anterior descending artery; OM = obtuse marginal; PDA = posterior descending artery; PLB = posterior lateral branch; Pso = psoriasis; RI = ramus intermedius; RCA = right coronary artery. The American Journal of Medicine 2015 128, 1325-1334.e2DOI: (10.1016/j.amjmed.2015.05.041) Copyright © 2015 Elsevier Inc. Terms and Conditions