Repackaged sodium valproate tablets – Meeting quality and adherence to ensure seizure control  Nichola Redmayne, Sherryl Robertson, Jutta Kockler, Victoria.

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Presentation transcript:

Repackaged sodium valproate tablets – Meeting quality and adherence to ensure seizure control  Nichola Redmayne, Sherryl Robertson, Jutta Kockler, Victoria Llewelyn, Alison Haywood, Beverley Glass  Seizure - European Journal of Epilepsy  Volume 31, Pages 108-111 (September 2015) DOI: 10.1016/j.seizure.2015.07.007 Copyright © 2015 British Epilepsy Association Terms and Conditions

Fig. 1 Visible rupturing of enteric coating after storage at 40°C; 75% RH for eight days. Seizure - European Journal of Epilepsy 2015 31, 108-111DOI: (10.1016/j.seizure.2015.07.007) Copyright © 2015 British Epilepsy Association Terms and Conditions

Fig. 2 Effect of exposure to various storage conditions on (A) tablet hardness and (B) weight and thickness. Number in parentheses=days of test. Weight (n=20), hardness (n=10), thickness (n=10); mean±2SD. Seizure - European Journal of Epilepsy 2015 31, 108-111DOI: (10.1016/j.seizure.2015.07.007) Copyright © 2015 British Epilepsy Association Terms and Conditions

Fig. 3 Sodium valproate tablets after 21 days of storage at accelerated (left), refrigerated (middle) and controlled room temperature (right) conditions. Seizure - European Journal of Epilepsy 2015 31, 108-111DOI: (10.1016/j.seizure.2015.07.007) Copyright © 2015 British Epilepsy Association Terms and Conditions