Responses to Crizotinib Can Occur in High-Level MET-Amplified Non–Small Cell Lung Cancer Independent of MET Exon 14 Alterations Rafael Caparica, MD,

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Responses to Crizotinib Can Occur in High-Level MET-Amplified Non–Small Cell Lung Cancer Independent of MET Exon 14 Alterations Rafael Caparica, MD, Cheng Tzu Yen, MD, Renata Coudry, MD, PhD, Sai-Hong Ignatius Ou, MD, PhD, Marileila Varella-Garcia, PhD, D. Ross Camidge, MD, PhD, Gilberto de Castro, MD, PhD Journal of Thoracic Oncology Volume 12, Issue 1, Pages 141-144 (January 2017) DOI: 10.1016/j.jtho.2016.09.116 Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

Figure 1 (A) Baseline computed tomography scan from case 1 showing large right lower lobe mass before crizotinib. (B) Fluorescence in situ hybridization analysis on a central nervous system resection specimen with MNNG HOS Transforming gene (MET) (SpectrumRed) and chromosome centromere 7 (CEP7) (SpectrumGreen) showing MET gene amplification (mean MET copies per cell = 20.53; mean CEP7 copies per cell = 2.07; MET/CEP7 ratio = 9.94). (C) Computed tomography scan after 2 months of treatment with crizotinib showing a near-complete response to therapy. Journal of Thoracic Oncology 2017 12, 141-144DOI: (10.1016/j.jtho.2016.09.116) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions