A comparison of covered vs bare expandable stents for the treatment of aortoiliac occlusive disease Bibombe P. Mwipatayi, MMed (Surg), FCS (SA), FRACS,

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Presentation transcript:

A comparison of covered vs bare expandable stents for the treatment of aortoiliac occlusive disease Bibombe P. Mwipatayi, MMed (Surg), FCS (SA), FRACS, Shannon Thomas, MBBS (Hons), Jackie Wong, MPH, Suzanna E.L. Temple, PhD, MBA, Vikram Vijayan, MRCS, FRCS, Mark Jackson, MD, FRACS, Sally A. Burrows, BMath Grad Dip Med Stat Journal of Vascular Surgery Volume 54, Issue 6, Pages 1561-1570.e1 (December 2011) DOI: 10.1016/j.jvs.2011.06.097 Copyright © 2011 Terms and Conditions

Fig 1 Flow chart shows the trial profile, including descriptions of the patients enrolled in the study and patients who were lost to follow-up. Journal of Vascular Surgery 2011 54, 1561-1570.e1DOI: (10.1016/j.jvs.2011.06.097) Copyright © 2011 Terms and Conditions

Fig 2 Kaplan-Meier curves are shown for freedom from binary restenosis for the intention-to-treat population. The sandwich variance estimate method (Lin and Wei) was used to determine the log-rank test adjusted for clustering (P = .0243). CI, Confidence interval; HR, hazard ratio. Journal of Vascular Surgery 2011 54, 1561-1570.e1DOI: (10.1016/j.jvs.2011.06.097) Copyright © 2011 Terms and Conditions

Fig 3 Kaplan-Meier curves are shown for freedom from stent occlusion for the intention-to-treat population. The sandwich variance estimate method was used to determine the log-rank test adjusted for clustering (P = .0874). CI, Confidence interval; HR, hazard ratio. Journal of Vascular Surgery 2011 54, 1561-1570.e1DOI: (10.1016/j.jvs.2011.06.097) Copyright © 2011 Terms and Conditions

Fig 4 Odds ratios of 18-month restenosis of >50% in selected patient subgroups. For most of the variables, the 95% confidence interval crosses the line of identity, indicating lack of statistical significance. The probability values for interaction indicate that only TransAtlantic Inter-Society Consensus (TASC) variables interacted on the level of statistical significance with the treatment modality. Journal of Vascular Surgery 2011 54, 1561-1570.e1DOI: (10.1016/j.jvs.2011.06.097) Copyright © 2011 Terms and Conditions

Fig 5 Kaplan-Meier curves are shown for freedom from binary restenosis for the type of stent used according to the TransAtlantic Inter-Society Consensus (TASC) C/D group. The sandwich variance estimate method was used to determine the log-rank test adjusted for clustering (P = .0056). CI, Confidence interval; HR, hazard ratio. Journal of Vascular Surgery 2011 54, 1561-1570.e1DOI: (10.1016/j.jvs.2011.06.097) Copyright © 2011 Terms and Conditions

Fig 6 Kaplan-Meier curves are shown for freedom from binary restenosis for the type of stent used according to the TransAtlantic Inter-Society Consensus (TASC) B group. There is no statistical difference between the two stents in patients with TASC B lesion. CI, Confidence interval; HR, hazard ratio. Journal of Vascular Surgery 2011 54, 1561-1570.e1DOI: (10.1016/j.jvs.2011.06.097) Copyright © 2011 Terms and Conditions

Fig 7 Kaplan-Meier curves for freedom from target vessel revascularization during the study period showed fewer reinterventions occurred in the covered-stent group (P = .006 at 12 months). CI, Confidence interval; OR, odds ratio; TVR, target vessel revascularization. Journal of Vascular Surgery 2011 54, 1561-1570.e1DOI: (10.1016/j.jvs.2011.06.097) Copyright © 2011 Terms and Conditions

Appendix Fig (online only) Kaplan-Meier survival estimates are shown for patients with TransAtlantic Inter-Society Consensus (TASC) B, C, and D lesions undergoing placement of the bare-metal stent and the covered (V12) stent. Journal of Vascular Surgery 2011 54, 1561-1570.e1DOI: (10.1016/j.jvs.2011.06.097) Copyright © 2011 Terms and Conditions