Preliminary assessment of the safety and efficacy of tanezumab in Japanese patients with moderate to severe osteoarthritis of the knee: a randomized,

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Presentation transcript:

Preliminary assessment of the safety and efficacy of tanezumab in Japanese patients with moderate to severe osteoarthritis of the knee: a randomized, double-blind, dose- escalation, placebo-controlled study H. Nagashima, M. Suzuki, S. Araki, T. Yamabe, C. Muto Osteoarthritis and Cartilage Volume 19, Issue 12, Pages 1405-1412 (December 2011) DOI: 10.1016/j.joca.2011.09.006 Copyright © 2011 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Study design. Osteoarthritis and Cartilage 2011 19, 1405-1412DOI: (10.1016/j.joca.2011.09.006) Copyright © 2011 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Patient disposition. Osteoarthritis and Cartilage 2011 19, 1405-1412DOI: (10.1016/j.joca.2011.09.006) Copyright © 2011 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 MMRM analysis of LS mean change from baseline in WOMAC pain (A), physical function (B), and stiffness (C) subscales, over time, FAS. SE: standard error. Osteoarthritis and Cartilage 2011 19, 1405-1412DOI: (10.1016/j.joca.2011.09.006) Copyright © 2011 Osteoarthritis Research Society International Terms and Conditions