Exposure to Nitrofurantoin During Early Pregnancy and Congenital Malformations: A Systematic Review and Meta-Analysis Ori Goldberg, MD, MPH, Myla Moretti,

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Presentation transcript:

Exposure to Nitrofurantoin During Early Pregnancy and Congenital Malformations: A Systematic Review and Meta-Analysis Ori Goldberg, MD, MPH, Myla Moretti, MSc, Amalia Levy, PHD, MPH, Gideon Koren, MD Journal of Obstetrics and Gynaecology Canada Volume 37, Issue 2, Pages 150-156 (February 2015) DOI: 10.1016/S1701-2163(15)30337-6 Copyright © 2015 Society of Obstetricians and Gynaecologists of Canada Terms and Conditions

Figure 1 Search flow chart Journal of Obstetrics and Gynaecology Canada 2015 37, 150-156DOI: (10.1016/S1701-2163(15)30337-6) Copyright © 2015 Society of Obstetricians and Gynaecologists of Canada Terms and Conditions

Figure 2 Major malformations: meta-analysis and forest plot (cohort studies) Journal of Obstetrics and Gynaecology Canada 2015 37, 150-156DOI: (10.1016/S1701-2163(15)30337-6) Copyright © 2015 Society of Obstetricians and Gynaecologists of Canada Terms and Conditions

Figure 3 Major malformations: meta-analysis and forest plot (case–control studies) Journal of Obstetrics and Gynaecology Canada 2015 37, 150-156DOI: (10.1016/S1701-2163(15)30337-6) Copyright © 2015 Society of Obstetricians and Gynaecologists of Canada Terms and Conditions

Figure 4 Cardiovascular malformations: meta-analysis and forest plot Journal of Obstetrics and Gynaecology Canada 2015 37, 150-156DOI: (10.1016/S1701-2163(15)30337-6) Copyright © 2015 Society of Obstetricians and Gynaecologists of Canada Terms and Conditions

Figure 5 Oral clefts: meta-analysis and forest plot Journal of Obstetrics and Gynaecology Canada 2015 37, 150-156DOI: (10.1016/S1701-2163(15)30337-6) Copyright © 2015 Society of Obstetricians and Gynaecologists of Canada Terms and Conditions

Figure 6 Left hypoplastic heart syndrome: meta-analysis and forest plot Journal of Obstetrics and Gynaecology Canada 2015 37, 150-156DOI: (10.1016/S1701-2163(15)30337-6) Copyright © 2015 Society of Obstetricians and Gynaecologists of Canada Terms and Conditions

Figure 7 Craniosynostosis: meta-analysis and forest plot Journal of Obstetrics and Gynaecology Canada 2015 37, 150-156DOI: (10.1016/S1701-2163(15)30337-6) Copyright © 2015 Society of Obstetricians and Gynaecologists of Canada Terms and Conditions

Figure 8 Funnel plot of papers included in meta-analysis Journal of Obstetrics and Gynaecology Canada 2015 37, 150-156DOI: (10.1016/S1701-2163(15)30337-6) Copyright © 2015 Society of Obstetricians and Gynaecologists of Canada Terms and Conditions