Reduction of Hepatitis B Surface Antigen and Covalently Closed Circular DNA by Nucleos(t)ide Analogues of Different Potency  Danny Ka-Ho Wong, Wai-Kay Seto, James Fung, Philip Ip, Fung-Yu Huang, Ching-Lung Lai, Man-Fung Yuen  Clinical Gastroenterology and Hepatology  Volume 11, Issue 8, Pages 1004-1010.e1 (August 2013) DOI: 10.1016/j.cgh.2013.01.026 Copyright © 2013 AGA Institute Terms and Conditions

Figure 1 Correlation between baseline qHBsAg and baseline serum HBV DNA (A and D), baseline intrahepatic total HBV DNA (B and E), and baseline cccDNA (C and F). (A–C) HBeAg-positive patients; (D–F) HBeAg-negative patients. Regression correlation lines of the HBV genotype B and C patient subgroups were shown as dotted lines and dashed lines, respectively. P values were calculated on the basis of the Fisher transformation of the Pearson correlation coefficients. Clinical Gastroenterology and Hepatology 2013 11, 1004-1010.e1DOI: (10.1016/j.cgh.2013.01.026) Copyright © 2013 AGA Institute Terms and Conditions

Figure 2 Baseline (dark gray boxes) and year 1 (light gray boxes) levels of qHBsAg, serum HBV DNA, and intrahepatic total HBV DNA and cccDNA in NA-treated (A) HBeAg-positive and (B) HBeAg-negative patients. The gray boxes depict the interquartile ranges, with the median value shown in the thick horizontal lines within the boxes. The error bars indicate the range of the lowest and highest data within 1.5 × interquartile range of the lower and upper quartiles, respectively. P values for the pair-wise comparison between the baseline and year 1 values are calculated by the Wilcoxon signed rank test and shown on top of each paired box. The lower limits of detection of assay are shown as horizontal dashed lines in each plot. Adv, adefovir; Clev, clevudine; Ent, entecavir; Lam, lamivudine; Tel, telbivudine. Clinical Gastroenterology and Hepatology 2013 11, 1004-1010.e1DOI: (10.1016/j.cgh.2013.01.026) Copyright © 2013 AGA Institute Terms and Conditions

Figure 3 Comparison of more potent and less potent NAs in terms of mean reduction in qHBsAg, serum HBV DNA, intrahepatic total HBV DNA, and cccDNA levels, with the standard deviations shown in error bars. Statistical differences were calculated by the independent-sample t test. (A) HBeAg-positive patients; (B) HBeAg-negative patients. Adv, adefovir; Clev, clevudine; Ent, entecavir; Lam, lamivudine; Tel, telbivudine. Clinical Gastroenterology and Hepatology 2013 11, 1004-1010.e1DOI: (10.1016/j.cgh.2013.01.026) Copyright © 2013 AGA Institute Terms and Conditions