Case 5 (type 3). Case 5 (type 3). A and B, Postmortem axial (A) and coronal (B) T2-weighted images show atrophied cerebellar cortices with dilation of.

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MR images of cytoarchitectural dysplasia

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Presentation transcript:

Case 5 (type 3). Case 5 (type 3). A and B, Postmortem axial (A) and coronal (B) T2-weighted images show atrophied cerebellar cortices with dilation of folial fissures and atrophied deep cerebellar white matter with a concave contour (arrowheads in B). Note the diffuse hyperintensities in the deep cerebellar white matter (arrows in B). There are diffuse hyperintensities and atrophy in the middle cerebellar peduncles and crossed hyperintensities and atrophy in the pontine base (A). Cerebellar deep white matter and dentate nucleus regions are not depicted precisely on the axial image (A). Hypointensities of the dentate nucleus region are conspicuous due to diffuse hyperintensities of the cerebellar deep white matter (B). C, A myelin-stained section corresponding to the white boxed area in B shows the diffuse pallor of the deep cerebellar white matter (arrowheads). Mild atrophy of the dentate nucleus and mild pallor of the white matter within and surrounding the dentate nucleus are seen (arrows) (Klüver-Barrera stain, original magnification ×5). D and E, Histologic findings of the boxed area in C show tissue rarefaction associated with loss of myelin (D) and axons (E) as well as gliosis (Klüver-Barrera stain, original magnification ×200, D; Bielschowsky stain, original magnification ×200, E). F, Immunohistochemical findings of the dentate nucleus (circled area in C) show diffuse ferritin deposition and preserved neurons with atrophy (arrows) (ferritin stain, original magnification ×200). E. Matsusue et al. AJNR Am J Neuroradiol 2009;30:1725-1730 ©2009 by American Society of Neuroradiology