Pathogenic Escherichia coli in inflammatory bowel diseases

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Presentation transcript:

Pathogenic Escherichia coli in inflammatory bowel diseases Arlette Darfeuille-Michaud, Jean-Frédéric Colombel Journal of Crohn's and Colitis Volume 2, Issue 3, Pages 255-262 (September 2008) DOI: 10.1016/j.crohns.2008.02.003 Copyright © 2008 European Crohn's and Colitis Organisation. Terms and Conditions

Figure 1 Colonization of the ileal mucosa by AIEC bacteria. Adherent-invasive E. coli adhere via type 1 pili to CEACAM6, that is the abnormally expressed by intestinal epithelial cells in CD patients. The invasive phenotype of AIEC allow the bacteria to cross the mucosal barrier. AIEC bacteria can survive and replicate within infected macrophages underlining the epithelial barrier and induce TNF-α secretion. Journal of Crohn's and Colitis 2008 2, 255-262DOI: (10.1016/j.crohns.2008.02.003) Copyright © 2008 European Crohn's and Colitis Organisation. Terms and Conditions

Figure 2 Proposed model for the association between E. coli and the pathogenesis of UC. Journal of Crohn's and Colitis 2008 2, 255-262DOI: (10.1016/j.crohns.2008.02.003) Copyright © 2008 European Crohn's and Colitis Organisation. Terms and Conditions

Figure 3 The bowel mucosa of a CD patient mounts a defective early acute immune response to invading bacteria, as compared to the normal bowel mucosa. This defective response allows bacterial influx, which leads to chronic inflammation in the gut. Journal of Crohn's and Colitis 2008 2, 255-262DOI: (10.1016/j.crohns.2008.02.003) Copyright © 2008 European Crohn's and Colitis Organisation. Terms and Conditions

Figure 4 Prevalence (proportion of individuals from which AIEC were isolated) and relative abundance (proportion of AIEC among the number of E. coli isolates analyzed) of AIEC isolated from biopsy samples of colonic mucosa. CD, CD patients (N=15); C, healthy controls (N=13). Journal of Crohn's and Colitis 2008 2, 255-262DOI: (10.1016/j.crohns.2008.02.003) Copyright © 2008 European Crohn's and Colitis Organisation. Terms and Conditions

Figure 5 Scanning electron micrographs of a PBMC aggregate induced by E. coli strain LF82 (Day 9 of incubation). Macrophages appear to be the predominant cell type, although lymphocytes are also present (arrow, left). The numerous villosities seen on the macrophages (right panel) suggest that these cells are intensely active. Bars represent 5 µm; degrees of magnification are as indicated. Journal of Crohn's and Colitis 2008 2, 255-262DOI: (10.1016/j.crohns.2008.02.003) Copyright © 2008 European Crohn's and Colitis Organisation. Terms and Conditions