Axon Degeneration: Too Much NMN Is Actually Bad? Michael S. Cohen  Current Biology  Volume 27, Issue 8, Pages R310-R312 (April 2017) DOI: 10.1016/j.cub.2017.02.058 Copyright © 2017 Elsevier Ltd Terms and Conditions

Figure 1 Model for the protective effects of NMN deamidase (NMNd). Axotomy results in the rapid degradation of NMNAT2, resulting in an increase in its substrate, nicotinamide adenine mononucleotide (NMN). SARM1, downstream (or in a parallel pathway) of NMNAT2 loss, is activated, which leads to axon degeneration. The axon-protective effects of NMNd may be due to lowering NMN levels by using it as a substrate for the synthesis of NaMN. Current Biology 2017 27, R310-R312DOI: (10.1016/j.cub.2017.02.058) Copyright © 2017 Elsevier Ltd Terms and Conditions