Full-Genome Scan for Linkage in 50 Families Segregating the Bipolar Affective Disease Phenotype  Carl Friddle, Rebecca Koskela, Koustubh Ranade, Joan.

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Full-Genome Scan for Linkage in 50 Families Segregating the Bipolar Affective Disease Phenotype  Carl Friddle, Rebecca Koskela, Koustubh Ranade, Joan Hebert, Michele Cargill, Chris D. Clark, Melvin McInnis, Sylvia Simpson, Francis McMahon, O. Colin Stine, Deborah Meyers, Jianfeng Xu, Dean MacKinnon, Theresa Swift-Scanlan, Kay Jamison, Susan Folstein, Mark Daly, Leonid Kruglyak, Thomas Marr, J. Raymond DePaulo, David Botstein  The American Journal of Human Genetics  Volume 66, Issue 1, Pages 205-215 (January 2000) DOI: 10.1086/302697 Copyright © 2000 The American Society of Human Genetics Terms and Conditions

Figure 1 Pedigrees of the 50 families studied. Only the generations used for genotyping are shown, and unaffected individuals as well as those with BPI, BPII, and RUP diagnoses are shown. The American Journal of Human Genetics 2000 66, 205-215DOI: (10.1086/302697) Copyright © 2000 The American Society of Human Genetics Terms and Conditions

Figure 2 Results from GENEHUNTER analysis. Each chromosome is separately plotted. The information content (scale in black on right-side ordinate) at each marker and at the midpoint between markers is shown. Also shown are the HLOD scores (scale on the leftside ordinate) for four models (see text), as well as for α = .5 (to estimate exclusion), again evaluated at markers and at the midpoint between markers. The American Journal of Human Genetics 2000 66, 205-215DOI: (10.1086/302697) Copyright © 2000 The American Society of Human Genetics Terms and Conditions

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