Splicing Misplaced Cell

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Splicing Misplaced Cell Eran Meshorer, Tom Misteli Cell Volume 122, Issue 3, Pages 317-318 (August 2005) DOI: 10.1016/j.cell.2005.07.016 Copyright © 2005 Elsevier Inc. Terms and Conditions

Figure 1 Regulatory Splicing of Pre-mRNA in the Platelet Cytoplasm Platelets are formed by budding of cytoplasm from megakaryocytes in the bone marrow. Although the splicing machinery is localized in the nucleus of megakaryocyte precursor cells, splicing factors begin to accumulate in the cytoplasm of mature megakaryocytes. The splicing components together with specific partially spliced pre-mRNAs are included in the forming anucleate platelets. Upon stimulation of platelets, the splicing machinery is activated and completes the splicing reaction, giving rise to a translatable mRNA. In this way, cytoplasmic splicing acts as a regulatory mechanism during platelet activation. Cell 2005 122, 317-318DOI: (10.1016/j.cell.2005.07.016) Copyright © 2005 Elsevier Inc. Terms and Conditions