Targeting CLEC12A with Chimeric Antigen Receptor T Cells Can Overcome the Chemotherapy Refractoriness of Leukemia Stem Cells Saad S. Kenderian, Marco.

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Presentation transcript:

Targeting CLEC12A with Chimeric Antigen Receptor T Cells Can Overcome the Chemotherapy Refractoriness of Leukemia Stem Cells Saad S. Kenderian, Marco Ruella, Olga Shestova, Michael Klichinsky, Miriam Kim, Craig Soderquist, Adam Bagg, Reshma Singh, Celeste Richardson, Regina Young, Carl H. June, Saar I. Gill Biology of Blood and Marrow Transplantation Volume 23, Issue 3, Pages S247-S248 (March 2017) DOI: 10.1016/j.bbmt.2016.12.413 Copyright © 2016 Terms and Conditions

Figure 1 Treatment with chemotherapy results in a relative increase of CLEC12A+ cells in patient derived AML xenograft models, indicating resistance of CLEC12A+ cells to chemotherapy. Biology of Blood and Marrow Transplantation 2017 23, S247-S248DOI: (10.1016/j.bbmt.2016.12.413) Copyright © 2016 Terms and Conditions

Figure 2 Induction chemotherapy followed by CLL1-CARTs, but not by untransduced T cells results in eradication of leukemia (A) and prolonged survival in AML xenografts (B). Biology of Blood and Marrow Transplantation 2017 23, S247-S248DOI: (10.1016/j.bbmt.2016.12.413) Copyright © 2016 Terms and Conditions