Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype Manuel A.R. Ferreira, PhD, Melanie C.

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Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype Manuel A.R. Ferreira, PhD, Melanie C. Matheson, PhD, Clara S. Tang, PhD, Raquel Granell, PhD, Wei Ang, PhD, Jennie Hui, PhD, Amy K. Kiefer, PhD, David L. Duffy, PhD, Svetlana Baltic, PhD, Patrick Danoy, PhD, Minh Bui, PhD, Loren Price, PhD, Peter D. Sly, FRACP, Nicholas Eriksson, PhD, Pamela A. Madden, PhD, Michael J. Abramson, PhD, Patrick G. Holt, FAA, Andrew C. Heath, DPhil, Michael Hunter, PhD, Bill Musk, FRACP, Colin F. Robertson, FRACP, Peter Le Souëf, FRACP, Grant W. Montgomery, PhD, A. John Henderson, MD, Joyce Y. Tung, PhD, Shyamali C. Dharmage, PhD, Matthew A. Brown, FRACP, Alan James, FRACP, Philip J. Thompson, FRACP, Craig Pennell, PhD, Nicholas G. Martin, PhD, David M. Evans, PhD, David A. Hinds, PhD, John L. Hopper, PhD Journal of Allergy and Clinical Immunology Volume 133, Issue 6, Pages 1564-1571 (June 2014) DOI: 10.1016/j.jaci.2013.10.030 Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Effect (OR ± 95% CI) of the top 11 loci on the mutually exclusive phenotypes of asthma without hay fever (A+H−) and hay fever without asthma (A−H+). Results are based on the comparison between 14,091 control subjects (no asthma and no hay fever, A−H−) and either 2,776 asthma without hay fever (A+H−) cases or 9,301 hay fever without asthma (A−H+) cases. Journal of Allergy and Clinical Immunology 2014 133, 1564-1571DOI: (10.1016/j.jaci.2013.10.030) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Quantile-quantile (QQ) plots for the GWAS of asthma-with-hayfever in the four individual cohorts, as well as in the meta-analysis of all studies. Journal of Allergy and Clinical Immunology 2014 133, 1564-1571DOI: (10.1016/j.jaci.2013.10.030) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 Main association results from the meta-analysis of four GWAS of asthma-with-hayfever. Journal of Allergy and Clinical Immunology 2014 133, 1564-1571DOI: (10.1016/j.jaci.2013.10.030) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E3 Regional association results (-log10(P-value), y-axis) for chromosome 8q21. The most-associated SNP is shown in purple, and the color of the remaining markers reflects the linkage disequilibrium (r2) with the top SNP. The recombination rate (second y-axis) is plotted in light blue and is based on the CEU 1000G population. Plots were generated using LocusZoom.E21 Journal of Allergy and Clinical Immunology 2014 133, 1564-1571DOI: (10.1016/j.jaci.2013.10.030) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E4 Regional association results (-log10(P-value), y-axis) for chromosome 16p13. The most-associated SNP is shown in purple, and the color of the remaining markers reflects the linkage disequilibrium (r2) with the top SNP. The recombination rate (second y-axis) is plotted in light blue and is based on the CEU 1000G population. Plots were generated using LocusZoom.E21 Journal of Allergy and Clinical Immunology 2014 133, 1564-1571DOI: (10.1016/j.jaci.2013.10.030) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions