Craig H Selzman, MD, Stephanie A Miller, MD, Alden H Harken, MD

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Presentation transcript:

Therapeutic implications of inflammation in atherosclerotic cardiovascular disease Craig H Selzman, MD, Stephanie A Miller, MD, Alden H Harken, MD The Annals of Thoracic Surgery Volume 71, Issue 6, Pages 2066-2074 (June 2001) DOI: 10.1016/S0003-4975(00)02597-2

Fig 1 The response to vascular injury. Therapeutic approaches target one or more points within this paradigm. (EC = endothelial cells; IEL = internal elastic lamina; PMNs = polymorphonuclear neutrophils; VSMC = vascular smooth muscle cell.) The Annals of Thoracic Surgery 2001 71, 2066-2074DOI: (10.1016/S0003-4975(00)02597-2)

Fig 2 Growth factor and cytokine relationships that are important in atherogenesis. These families of proteins act in autocrine, juxtacrine, and paracrine fashion to communicate among and between circulating and resident vascular cells. (PDGF = platelet-derived growth factors; FGF = fibroblast growth factors; EGF = epidermal growth factors; IGF = insulin-like growth factors; TGF = transforming growth factors; VEGF = vascular endothelial growth factor; M-CSF = macrophage colony-stimulating factors; GM-CSF = granulocyte-macrophage colony-stimulating factors; MCP = monocyte chemotaxic proteins; MIP = macrophage inflammatory proteins; IL = interleukin; TNF = tumor necrosis factors; IFN = interferons.) The Annals of Thoracic Surgery 2001 71, 2066-2074DOI: (10.1016/S0003-4975(00)02597-2)

Fig 3 Global intracellular signal patterns involved with atherogensis. Peptide growth factors, cytokines, and stress activators are mediated by a group of receptors bound by intracellular protein kinases. Receptor-mediated events rely on multiple cytoplasmic signaling intermediates that activate transcription or translational factors. These factors transduce signals to the nucleus, influencing gene transcription, translation, and cell-cycle mechanics. Cumulatively, these signals promulagate the inflammatory and atherogenic response. The Annals of Thoracic Surgery 2001 71, 2066-2074DOI: (10.1016/S0003-4975(00)02597-2)

Fig 4 Nuclear factor kappa B (NFκB) and atherogenesis. This intracellular transcription factor is activated by a variety of stimuli, is present in all vascular cells, and is a central mediator regulating multiple atherogenic events. (LDL = low-density lipoprotein; VSMC = vascular smooth muscle cell.) The Annals of Thoracic Surgery 2001 71, 2066-2074DOI: (10.1016/S0003-4975(00)02597-2)