Hyporeninemic hypoaldosteronism from secondary amyloidosis Fumi Takemoto, Yoshifumi Ubara, Shinya Kaname, Hideyuki Katori, Naoki Sawa, Junichi Hoshino, Tatsuya Suwabe, Yasushi Higa, Shohei Nakanishi, Michio Nagata, Kenichi Ohashi, Kenmei Takaichi  Kidney International  Volume 74, Issue 4, (August 2008) DOI: 10.1038/ki.2008.14 Copyright © 2008 International Society of Nephrology Terms and Conditions

Figure 1 Renal biopsy. There is marked amyloid deposition along the afferent arteriole including the juxtaglomerular cells. Periodic acid–methenamine silver staining (original magnification × 400). Kidney International 2008 74, DOI: (10.1038/ki.2008.14) Copyright © 2008 International Society of Nephrology Terms and Conditions

Figure 2 Biopsy specimens. (a) Congo red staining shows diffuse amyloid deposition on the renal vasculatures and glomerulus, including afferent arteriole (original magnification × 100). (b) Immunostaining for amyloid A was positive (original magnification × 200). (c) Amyloid fibrils on electron microscopy (original magnification × 4500). The amyloid fibrils, which had a diameter of 13nm, were randomly distributed. Kidney International 2008 74, DOI: (10.1038/ki.2008.14) Copyright © 2008 International Society of Nephrology Terms and Conditions