Removal of prostaglandin E2 and increased intraoperative blood pressure during modified ultrafiltration in pediatric cardiac surgery Kazuto Yokoyama,

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Presentation transcript:

Removal of prostaglandin E2 and increased intraoperative blood pressure during modified ultrafiltration in pediatric cardiac surgery Kazuto Yokoyama, MD, Shin Takabayashi, MD, PhD, Takuya Komada, MD, PhD, Koji Onoda, MD, PhD, Yoshihide Mitani, MD, PhD, Hideki Iwata, ME, Hideto Shimpo, MD, PhD The Journal of Thoracic and Cardiovascular Surgery Volume 137, Issue 3, Pages 730-735 (March 2009) DOI: 10.1016/j.jtcvs.2008.09.017 Copyright © 2009 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Kallikrein–kinin system and prostaglandin E2. The Journal of Thoracic and Cardiovascular Surgery 2009 137, 730-735DOI: (10.1016/j.jtcvs.2008.09.017) Copyright © 2009 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Change in systolic blood pressure during operation. Asterisk indicates P < .01. MUF, Modified ultrafiltration; CPB, cardiopulmonary bypass; Postop, after operation. The Journal of Thoracic and Cardiovascular Surgery 2009 137, 730-735DOI: (10.1016/j.jtcvs.2008.09.017) Copyright © 2009 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 Change in serum prostaglandin E2 level during operation. Asterisk indicates P < .01. MUF, Modified ultrafiltration; CPB, cardiopulmonary bypass; Postop, after operation. The Journal of Thoracic and Cardiovascular Surgery 2009 137, 730-735DOI: (10.1016/j.jtcvs.2008.09.017) Copyright © 2009 The American Association for Thoracic Surgery Terms and Conditions

Figure 4 Correlation between serum prostaglandin E2 level and systolic blood pressure during operation. There was negative correlation between serum prostaglandin E2 level and systolic blood pressure (R = −0.392, y = −0.1801x + 79.7, P < .01). The Journal of Thoracic and Cardiovascular Surgery 2009 137, 730-735DOI: (10.1016/j.jtcvs.2008.09.017) Copyright © 2009 The American Association for Thoracic Surgery Terms and Conditions

Figure 5 Changes in serum prostaglandin E2 levels and systolic blood pressure during modified ultrafiltration (MUF). In almost all cases, serum prostaglandin E2 level decreased and systolic BP increased during modified ultrafiltration. The Journal of Thoracic and Cardiovascular Surgery 2009 137, 730-735DOI: (10.1016/j.jtcvs.2008.09.017) Copyright © 2009 The American Association for Thoracic Surgery Terms and Conditions

Figure 6 Subset analysis by body weight. Asterisk indicates P < .01. Group L, Patients with body weight <10 kg; Group H, patients with body weight >10 kg; MUF, modified ultrafiltration; N.S., not significant; CPB, cardiopulmonary bypass; Postop, after operation. The Journal of Thoracic and Cardiovascular Surgery 2009 137, 730-735DOI: (10.1016/j.jtcvs.2008.09.017) Copyright © 2009 The American Association for Thoracic Surgery Terms and Conditions