Gene-gene interactions and risk of recurrent miscarriages in carriers of endocrine gland–derived vascular endothelial growth factor and prokineticin receptor.

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Presentation transcript:

Gene-gene interactions and risk of recurrent miscarriages in carriers of endocrine gland–derived vascular endothelial growth factor and prokineticin receptor polymorphisms Mei-Tsz Su, M.D., Ph.D., Sheng-Hsiang Lin, Ph.D., Yi-Chi Chen, Ph.D., Pao-Lin Kuo, M.D. Fertility and Sterility Volume 102, Issue 4, Pages 1071-1077.e3 (October 2014) DOI: 10.1016/j.fertnstert.2014.06.042 Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

Figure 1 (A) Distribution of high-risk and low-risk genotypes in the best two-locus model [PROKR1 (I379V) and PROKR2 (V331M)]. High-risk (dark shading) and low-risk (light shading) genotypes associated with recurrent miscarriages show two-locus interaction. The numbers of recurrent miscarriage (RM) subjects (left black bar in boxes) and control subjects (right black bar in boxes) are shown for each genotype combination. ∗The genotype combination that confers significant less susceptibility to RM (P<.05). (B) Distribution of high-risk and low-risk genotypes in the best three-locus model [EG-VEGF (V67I), PROKR1 (I379V), and PROKR2 (V331M)]. High-risk (dark shading) and low-risk (light shading) genotypes associated with recurrent miscarriages show three-locus interaction. The numbers of RM subjects (left black bar in boxes) and control subjects (right black bar in boxes) are shown for each genotype combination. Fertility and Sterility 2014 102, 1071-1077.e3DOI: (10.1016/j.fertnstert.2014.06.042) Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 1 Endocrine gland–derived vascular endothelial growth factor (EG-VEGF) variants identified in patients with recurrent miscarriage and control subjects. Schematic representation of variants identified in the EG-VEGF gene, with only one nonsynonymous variant (V67I) among them. Fertility and Sterility 2014 102, 1071-1077.e3DOI: (10.1016/j.fertnstert.2014.06.042) Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions