Prognostic Impact of CD204-Positive Macrophages in Lung Squamous Cell Carcinoma: Possible Contribution of Cd204-Positive Macrophages to the Tumor-Promoting.

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Prognostic Impact of CD204-Positive Macrophages in Lung Squamous Cell Carcinoma: Possible Contribution of Cd204-Positive Macrophages to the Tumor-Promoting Microenvironment Shunki Hirayama, MD, Genichiro Ishii, MD, PhD, Kanji Nagai, MD, PhD, Shotaro Ono, MD, Motohiro Kojima, MD, PhD, Chisako Yamauchi, MD, PhD, Keiju Aokage, MD, PhD, Tomoyuki Hishida, MD, PhD, Junji Yoshida, MD, PhD, Kenji Suzuki, MD, PhD, Atsushi Ochiai, MD, PhD Journal of Thoracic Oncology Volume 7, Issue 12, Pages 1790-1797 (December 2012) DOI: 10.1097/JTO.0b013e3182745968 Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 1 A, Immunohistochemical staining of squamous cell carcinoma with antihuman CD204 antibody for tumor-associated macrophages in the stroma and nest. Cases with a high number of CD204 (+) TAMs in the stroma, and B, a low number of CD204 (+) TAMs in the stroma. C, Cases with a high number of CD204 (+) TAMs in the nest, and D, a low number of CD204 (+) TAMs in the nest. TAMs, tumor-associated macrophages. Journal of Thoracic Oncology 2012 7, 1790-1797DOI: (10.1097/JTO.0b013e3182745968) Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 2 Kaplan–Meier analysis stratified according to a high or low number of CD204 (+) TAMs in the stroma. The Kaplan–Meier analysis for overall survival and recurrence-free survival according to the numbers of CD204 (+) TAMs in the stroma are shown for all stages A, for p-stage I, B, for p-stage II, C, and for p-stage III, D,. TAMs, tumor-associated macrophages. Journal of Thoracic Oncology 2012 7, 1790-1797DOI: (10.1097/JTO.0b013e3182745968) Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 3 Immunohistochemical staining of squamous cell carcinoma tissue with antihuman Foxp3 antibody and antihuman CD34 antibody. A, Cases with a high number of Foxp3 positive lymphocytes, and B, a low number of Foxp3 positive lymphocytes. C, Cases with a high MVD, and D, a low MVD. E, Correlations between the numbers of CD204 (+) TAMs in the stroma and the MVD, F, the number of Foxp3 (+) lymphocytes. TAMs, tumor-associated macrophages; MVD, microvessel density. Journal of Thoracic Oncology 2012 7, 1790-1797DOI: (10.1097/JTO.0b013e3182745968) Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 4 Relative mRNA expression in CD204-low and CD204-high cases. The levels of mRNA expression shown are the ratios of expression in cancer tissues relative to the expression in noncancerous tissues, as determined using a quantitative real-time polymerase chain reaction. MCP-1, monocyte chemoattractant protein-1; TGF β, transforming growth factor β; VEGF, vascular endothelial growth factor; IL-10, interleukins-10. Journal of Thoracic Oncology 2012 7, 1790-1797DOI: (10.1097/JTO.0b013e3182745968) Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions