Overview of Organic bioelectronics Organic Bio-electronics: Understanding the relationship between natural and artificial biomaterials for bio-electronics applications Godspower Omokhunu Abstract Organic bioelectronics encompasses both academic and industrial interest and seeks to bridge the gap between electronics and biology by integrating biological materials like proteins, antibodies, DNA, and cells with electronic elements. Using the review-centric theory, a model was developed and presented to capture the dynamic interaction of organic bioelectronics, material sources, properties and its implications on modern technologies. Limitation to this research is that the empirical data is limited to 4 dependent variables which do not present a conclusive theory about the subject matter. Therefore, In this review, we explore the interfacing of synthetic material (PVDF) and a novel natural material (electric organ of Electrophorus electricus) by reviewing their properties, fabrication methods to create a composite that has application in a variety of bioelectronics devices. Communication Interface Between Electronic Components And Biological System Figure 1 – Organic bioelectronics and its dependent factors Organic bioelectronics can be considered as a function of the above listed variables. It can be referred to as a field that incorporate biological materials with electronic devices to improve the wellbeing of living organism[3]. The application of organic electronics at the interface with life sciences creates many opportunities and currently encompasses many different applications. Figure 2 – Current different R&D strategies in the field of bioelectronics It is possible to tailor structures on the atomic scale with controlled electrical, dielectric, chemical or thermal properties for future potential applications in a variety of electronic, photonic, magnetic, mechanical and/or molecular recognition devices. Structural control is done by using new preparation technologies and by applying analytical tools to investigate organic/organic and organic / inorganic interfaces even on the atomic scale [1]. Overview of Organic bioelectronics Challenges The empirical data is limited to 4 dependent variables which do not present a conclusive theory about organic bioelectronics Long-term stability of materials. Parallelism of information processing and fabrication methods. Easy energy dissipation through “soft” materials [2]. Conclusion The work highlighted here represents just a tiny piece of the enormity of research and development done in the field of organic bioelectronics. It describes the interdisciplinary efforts, aiming to develop novel communication interfaces between electronic components and biological systems Although great progress has been made, there are still certain sustainable challenges in designs and applications of bioelectronics. further development of material properties, design of devices is necessary will aid in making organic bioelectronics devices useful for a number of applications. REFERENCE Göpel, W., Bioelectronics and nanotechnologies1Presented at “Biosensors 1996” in Bangkok, Thailand.1. Biosensors and Bioelectronics, 1998. 13(6): p. 723-728. Irimia-Vladu, M., et al., Natural resin shellac as a substrate and a dielectric layer for organic field-effect transistors. Green Chemistry, 2013. 15(6): p. 1473-1476. Strakosas, X., M. Bongo, and R.M. Owens, The organic electrochemical transistor for biological applications. Journal of Applied Polymer Science, 2015. 132(15).