Volume 9, Issue 1, Pages (January 2010)

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Volume 9, Issue 1, Pages 39-45 (January 2010) Assessment of brain tissue injury after moderate hypothermia in neonates with hypoxic– ischaemic encephalopathy: a nested substudy of a randomised controlled trial Mary Rutherford, FRCR, Luca A Ramenghi, MD, A David Edwards, FMedSci, Peter Brocklehurst, FFPH, Henry Halliday, MD, Malcolm Levene, FMedSci, Brenda Strohm, RGN, Marianne Thoresen, MD, Andrew Whitelaw, FRCPCH, Denis Azzopardi, FRCPCH The Lancet Neurology Volume 9, Issue 1, Pages 39-45 (January 2010) DOI: 10.1016/S1474-4422(09)70295-9 Copyright © 2010 Elsevier Ltd Terms and Conditions

Figure 1 MRI appearances in neonatal hypoxic–ischaemic encephalopathy (A-C) T1-weighted images in the transverse plane. (A) Normal neonatal brain with linear high signal intensity representing myelin in the posterior limb of the internal capsule (arrow). (B) Moderate basal ganglia and thalamic lesions with abnormal increased signal intensity in the globus (top arrow), putamen (middle arrow), and thalamus (bottom arrow). There is no normal linear high signal intensity from the intervening posterior limb of the internal capsule. (C) Cortical lesions. There is abnormal increased signal intensity in the cortex around the central sulcus (arrow head) and along the interhemispheric fissure. Abnormal low signal intensity is seen in the adjacent subcortical white matter (arrow). (D–F) T2-weighted images in the transverse plane. (D) Mild lesions in the basal ganglia. There are small bilateral foci of abnormal low signal intensity in the lentiform nuclei (arrow). (E) Mild white matter lesions. There is diffuse and slightly increased signal intensity in the periventricular white matter (arrow). (F) Severe basal ganglia and thalamic and white matter lesions. There is mixed abnormal signal intensity throughout the basal ganglia and thalami. The intervening posterior limb of the internal capsule shows abnormal high signal intensity with no evidence of low signal intensity from myelin (arrow). The hemispheric white matter has diffuse abnormal high signal intensity throughout. The Lancet Neurology 2010 9, 39-45DOI: (10.1016/S1474-4422(09)70295-9) Copyright © 2010 Elsevier Ltd Terms and Conditions

Figure 2 Study profile The Lancet Neurology 2010 9, 39-45DOI: (10.1016/S1474-4422(09)70295-9) Copyright © 2010 Elsevier Ltd Terms and Conditions