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OUTCOME MEASURES IN PsA: IMMUNOHISTOLOGY Oliver FitzGerald.

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Figure 3 The induction of anti-DNA antibodies by bacterial DNA

Nat. Rev. Rheumatol. doi: /nrrheum

Nat. Rev. Cardiol. doi: /nrcardio

Figure 3 Connexins in cartilage

Figure 1 Historical evolution of the clinical classification and

Figure 3 Metabolism in homeostatic chondrocytes

Figure 1 Rheumatoid arthritis development over time in relation to the level of inflammation Figure 1 | Rheumatoid arthritis development over time in relation.

Nat. Rev. Rheumatol. doi: /nrrheum

Figure 3 Extracellular stimuli to HSC activation

Nat. Rev. Rheumatol. doi: /nrrheum

Nat. Rev. Rheumatol. doi: /nrrheum

Nat. Rev. Rheumatol. doi: /nrrheum

Figure 1 Induction of immune tolerance

Figure 4 Simplified T cell and antigen presenting

Figure 3 Proposed mechanisms underlying the links

Nat. Rev. Rheumatol. doi: /nrrheum

Figure 5 Defects in the JAK–STAT signalling pathway

Nat. Rev. Rheumatol. doi: /nrrheum

Figure 4 C-Terminal protein citrullination catalysed

Figure 2 Targeted versus untargeted metabolomics approaches

Figure 1 Metabolic profiling as a tool for studying rheumatic diseases

Figure 3 Mechanisms by which oestradiol reduces

Nat. Rev. Rheumatol. doi: /nrrheum

Figure 3 Metabolic configurations of M1 and M2 macrophages

Figure 3 Simplified EULAR and GRAPPA

Figure 2 Simplified EULAR and GRAPPA

Figure 3 Transcriptome studies performed in the target

Figure 2 Shared genetic loci in systemic autoimmune diseases

Figure 5 Regulation of inflammation by metabolites

Figure 1 Location of HLA variants known to be associated

Figure 4 Altered metabolism in chondrocytes in osteoarthritis

Figure 3 Endogenous repair of double-strand DNA breaks

Nat. Rev. Rheumatol. doi: /nrrheum

Figure 3 Strategies to achieve therapeutic inhibition of IL-1

Figure 1 Pharmacodynamics of methotrexate in RA

Figure 3 Hypothetical mechanisms of smoking-associated

Nat. Rev. Rheumatol. doi: /nrrheum

Nat. Rev. Rheumatol. doi: /nrrheum

Figure 2 Interaction effects between heterozygous HLA‑DRB1

Nat. Rev. Rheumatol. doi: /nrrheum

Figure 2 Microbiota and osteoimmunology

Nat. Rev. Rheumatol. doi: /nrrheum

Figure 3 Statistical approaches for the analysis of metabolomic data

Figure 6 Lack of IRF5 causes a reduction in neutrophil influx

Figure 5 The role of Ly6Chi and Ly6Clo monocytes

Figure 3 Effect of sialylated glycoforms on IgG activity

Figure 3 Multi-hit model for autoimmune diseases

Figure 1 Simplified EULAR and GRAPPA

Nat. Rev. Rheumatol. doi: /nrrheum

Nat. Rev. Rheumatol. doi: /nrrheum

Figure 1 Research advances in osteoarthritis management

Figure 1 Overview of biosimilar product development

Nat. Rev. Rheumatol. doi: /nrrheum

Nat. Rev. Rheumatol. doi: /nrrheum

Figure 6 Metabolism of pterins

Figure 1 Principles for the diagnosis and management of osteoarthritis

Nat. Rev. Rheumatol. doi: /nrrheum

Nat. Rev. Cardiol. doi: /nrcardio

Nat. Rev. Rheumatol. doi: /nrrheum

Figure 1 Chronic inflammation and DNA damage in people with SLE

Figure 3 Nuclear-penetrating autoantibodies and synthetic lethality

MexT-associated downregulation of oprD expression.

Figure 3 Underlying mechanisms of TREG cells in atherosclerosis

Figure 1 Patterns of joint and organ involvement in rheumatic disease

Nat. Rev. Rheumatol. doi: /nrrheum

Figure 1 The role of macrophages in RA

Nat. Rev. Urol. doi: /nrurol

Systems medicine-based approaches in interstitial lung diseases seek to analyse biological products (e.g. Systems medicine-based approaches in interstitial.

Nat. Rev. Rheumatol. doi: /nrrheum

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Nat. Rev. Rheumatol. doi:10.1038/nrrheum.2016.175 Figure 2 Potential mechanisms of action of low-dose methotrexate in rheumatoid arthritis Figure 2 | Potential mechanisms of action of low-dose methotrexate in rheumatoid arthritis. Several mechanisms have been proposed to explain the observed clinical effects of methotrexate in rheumatoid arthritis, including antagonism of folate-dependent processes, stimulation of adenosine signalling, inhibition of methyl-donor production, generation of reactive oxygen species, downregulation of adhesion-molecule expression, modification of cytokine profiles and downregulation of eicosanoids and matrix metalloproteinases (MMPs). Brown, P. M. et al. (2016) Mechanism of action of methotrexate in rheumatoid arthritis, and the search for biomarkers Nat. Rev. Rheumatol. doi:10.1038/nrrheum.2016.175