Figure 2 Immunopathologic analysis of all 3 Rasmussen encephalitis cases Immunopathologic analysis of all 3 Rasmussen encephalitis cases (A) Perivascular.

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Figure 2 Immunopathologic analysis of all 3 Rasmussen encephalitis cases Immunopathologic analysis of all 3 Rasmussen encephalitis cases (A) Perivascular cuffing (hematoxylin and eosin [H&E]), prominent astrogliosis (GFAP), strong microglial activation (HLA-DR staining), T-cell infiltrates (CD3+NeuN), and absence of B cells (CD20) are shown. (B) Representative images showing CD8+ T cells infiltrating the tissue, some of them in proximity or direct contact to neurons (CD8+NeuN) and also, in all 3 cases, CD4+ T cells as well as γδ T cells (γδ-TCR) infiltrating the brain parenchyma. For CD8+NeuN, CD4, and γδ-TCR, a higher magnification of the small regions in squares is shown on the top right inset of each image. Scale bar = 100 μm except for GFAP and HLA-DR = 200 μm. GFAP = glial fibrillary acidic protein; HLA-DR = human leukocyte antigen; RE = Rasmussen encephalitis; TCR = T-cell receptor. Faiez Al Nimer et al. Neurol Neuroimmunol Neuroinflamm 2018;5:e419 Copyright © 2017 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology