Fig 6.1 Drug released by diffusion Drug diffusion through additional polymer coating Drug release by swelling of coating Drug release by coating erosion Polymer drug conjugate cleaved by hydrolysis or enzymic action Biodegradable polymeric stent Drug loaded in stent reservoir Stent Polymer Drug Fig 6.1

Thrombus organization Thrombus formation Anti-inflammatory drugs SMC activation Endothelial denudation Vascular injury Angioplasty Proliferation DNA synthesis Restenosis Extracellular matrix formation ECM modulators Antiproliferative agents Thrombus organization Thrombus formation Anti-inflammatory drugs Negative arterial remodeling Migration Antimigratory Recoil Mechanical stretch Stent Antiplatelet therapy Fig 6.2

Fig 6.3 Smooth muscle cells Tissue factor Cholesterol Necrotic core Foam cells Rupture of plaque Platelets Vascular endothelium Atherosclerotic plaque Vessel wall Thrombus Fig 6.3