Endothelial sodding of the permaflow prosthetic coronary artery bypass conduit Michael R Phillips, MD, Hiroki Yamaguchi, MD, Virginia M Miller, PhD, Stuart.

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Presentation transcript:

Endothelial sodding of the permaflow prosthetic coronary artery bypass conduit Michael R Phillips, MD, Hiroki Yamaguchi, MD, Virginia M Miller, PhD, Stuart Williams, PhD, James J Morris, MD, Hartzell V Schaff, MD The Annals of Thoracic Surgery Volume 66, Issue 4, Pages 1191-1197 (October 1998) DOI: 10.1016/S0003-4975(98)00780-2

Fig 1 In vivo graft placement. Note that only the graft proximal to the coronary artery anastomosis contained endothelium. The proximal native circumflex has been ligated so that all distal myocardial blood flow depends on the Permaflow graft. (©1996 Mayo Foundation; reprinted by permission of Mayo Foundation.) The Annals of Thoracic Surgery 1998 66, 1191-1197DOI: (10.1016/S0003-4975(98)00780-2)

Fig 2 (A) Scanning electron micrograph from midsegment of a sodded graft. Note a confluent cellular layer resembling endothelium and the absence of adherent platelets, leukocytes, or fibrin. (B) Scanning electron micrograph of sodded graft distal to the coronary anastomosis. This segment was not treated with the sodding procedure. Note the absence of endothelial cells. (C) Scanning electron micrograph of midgraft segment of unsodded conduit. Note adherent thrombus and leukocytes and the absence of cells resembling endothelium. (D) Scanning electron micrograph of standard expanded polytetrafluoroethylene graft before sodding or implant for comparison. (×500 before 49% reduction.) The Annals of Thoracic Surgery 1998 66, 1191-1197DOI: (10.1016/S0003-4975(98)00780-2)

Fig 3 Hematoxylin and eosin staining of sodded midgraft segment. Note confluent cellular layer lining the blood-contacting surface of the expanded polytetrafluoroethylene graft and the absence of adherent thrombus. (×20.) The Annals of Thoracic Surgery 1998 66, 1191-1197DOI: (10.1016/S0003-4975(98)00780-2)

Fig 4 Sodded midgraft segment reacted with antibodies to α-smooth muscle actin. Cells within the subendothelial matrix stained positively, suggesting the cells are of smooth muscle origin. (×40 before 50% reduction.) The Annals of Thoracic Surgery 1998 66, 1191-1197DOI: (10.1016/S0003-4975(98)00780-2)

Fig 5 Significant difference in release of vasodilator substances between sodded and unsodded conduits, as detected by superfusion bioassay (n = 8; p < 0.03). The Annals of Thoracic Surgery 1998 66, 1191-1197DOI: (10.1016/S0003-4975(98)00780-2)