Lithium-associated nephropathy in the renal allograft Cristian Rodelo-Haad, Maria L. Agüera, Rosa Ortega, Ana Martinez-Lopez, M. Dolores Navarro, Alberto Rodriguez-Benot, Pedro Aljama  Kidney International  Volume 93, Issue 1, (January 2018) DOI: 10.1016/j.kint.2017.08.032 Copyright © 2017 International Society of Nephrology Terms and Conditions

Figure 1 Kidney graft biopsy findings showing glomerulomegaly, interstitial nephritis, tubular atrophy, and microcysts in distal convoluted tubules (red arrows; hematoxylin and eosin stain ×100). To optimize viewing of this image, please see the online version of this article at www.kidney-international.org. Kidney International 2018 93, DOI: (10.1016/j.kint.2017.08.032) Copyright © 2017 International Society of Nephrology Terms and Conditions

Figure 2 Immunohistochemical of paraffin-embedded kidney graft biopsy. Cytokeratin-18 staining is a useful tool to identify microcysts in the distal nephron segments (red arrows; cytokeratin-18 ×40). To optimize viewing of this image, please see the online version of this article at www.kidney-international.org. Kidney International 2018 93, DOI: (10.1016/j.kint.2017.08.032) Copyright © 2017 International Society of Nephrology Terms and Conditions

Figure S1 Periodic acid–Schiff–positive material on the luminal surface of tubular cells (red arrow). The periodic acid–Schiff–positive granularity may be due to glycogen accumulation because it disappears after treatment with diastase (periodic acid–Schiff ×100). Kidney International 2018 93, DOI: (10.1016/j.kint.2017.08.032) Copyright © 2017 International Society of Nephrology Terms and Conditions

Figure S2 Serum lithium (Li) and creatinine levels (SCr) throughout follow-up after transplantation. Biopsy was performed because of impairment of kidney allograft function (arrowhead). Shaded area indicates normal range for serum lithium levels. Kidney International 2018 93, DOI: (10.1016/j.kint.2017.08.032) Copyright © 2017 International Society of Nephrology Terms and Conditions