Formyl peptide receptor 1 (FPR1) is expressed on pulmonary epithelial cells with myeloid and parenchymal cell FPR1 contributing to neutrophil recruitment.

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Presentation transcript:

Formyl peptide receptor 1 (FPR1) is expressed on pulmonary epithelial cells with myeloid and parenchymal cell FPR1 contributing to neutrophil recruitment and alveolar protein leak during lung injury. Formyl peptide receptor 1 (FPR1) is expressed on pulmonary epithelial cells with myeloid and parenchymal cell FPR1 contributing to neutrophil recruitment and alveolar protein leak during lung injury. Expression of epithelial FPR1 was determined by RT-PCR (A; 1–3=separate mice; ntc—no template control) of flow sorted mouse epithelial cells (EpCam1/E-cadherin positive) and immunohistochemistry (×1000 magnification) on mouse lung sections (B; representative images n=3 per group). Following re-engraftment bone marrow chimaeras (WT & Fpr1−/−) were injured with intratracheal HCl. Bronchoalveolar lavage fluid (BALF) total protein (C) and IgM (D) were quantified 24 hours after injury. Total BALF cell number (F) and neutrophil (G) and monocyte/macrophage count (H) were assessed (representative cytocentrifuge preparations of WT/WT and Fpr/Fpr BALF shown; ×400 magnification (E)). n=3–6/group *p<0.05, **p<0.001, one-way ANOVA. David A Dorward et al. Thorax 2017;72:928-936 Copyright © BMJ Publishing Group Ltd & British Thoracic Society. All rights reserved.