Pegylated interferons

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Presentation transcript:

Pegylated interferons Umaprasanna S Karnam, MD, K.Rajender Reddy, MD Clinics in Liver Disease Volume 7, Issue 1, Pages 139-148 (February 2003) DOI: 10.1016/S1089-3261(02)00072-7

Fig. 1 Chemical structures of some representative polyethylene glycol molecules. [MPEG, monomethoxypoly (ethylene glycol)]. Clinics in Liver Disease 2003 7, 139-148DOI: (10.1016/S1089-3261(02)00072-7)

Fig. 2 Effects of pegylation on half-life and antiviral activity. As the molecular weight of the attached PEG moiety increases, the antiviral activity decreases, but the serum half-life increases. Clinics in Liver Disease 2003 7, 139-148DOI: (10.1016/S1089-3261(02)00072-7)