M-MDSCs decreased expression of CD40 and MHC II

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M-MDSCs decreased expression of CD40 and MHC II M-MDSCs decreased expression of CD40 and MHC II. (A) Representative flow plots showing CD40 expression of B cells stimulated with LPS in the presence or absence of M-MDSCs. M-MDSCs decreased expression of CD40 and MHC II. (A) Representative flow plots showing CD40 expression of B cells stimulated with LPS in the presence or absence of M-MDSCs. (B) Geometric MFIs of CD40 on the B cell compartment. (C and F) Representative flow plots showing MHC II expression of B cells stimulated with (C) αCD40 + IL-4 or (F) LPS in the presence or absence of M-MDSCs. (D and G) Geometric MFIs of MHCII on the B cell compartment when stimulated with (D) αCD40 + IL-4 or (G) LPS. (E and H) Percent suppression of MHC II geometric MFI on different developmental subsets of (E) αCD40 + IL-4–stimulated or (H) LPS-stimulated B cells by M-MDSCs. Data shown in (A)–(H) are from a representative experiment, with a similar pattern of results observed in four experiments. Statistics in (E) and (H) represent comparisons of MFI of B cells within the indicated subset in the presence or absence of M-MDSCs. *p < 0.05, **p < 0.01,***p < 0.001. Jessica L. Rastad, and William R. Green ImmunoHorizons 2018;2:87-106 Copyright © 2018 The Authors