DH E2 infusion significantly increased phosphorylation of the p42 isoform of ERK (A) and of Akt (B) in the DH of OVX females, but not sham GDX males. DH.

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From: Sex Differences in Hepatic Heme Oxygenase Expression and Activity Following Trauma and Hemorrhagic Shock Arch Surg. 2003;138(12): doi: /archsurg

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DH E2 infusion significantly increased phosphorylation of the p42 isoform of ERK (A) and of Akt (B) in the DH of OVX females, but not sham GDX males. DH E2 infusion significantly increased phosphorylation of the p42 isoform of ERK (A) and of Akt (B) in the DH of OVX females, but not sham GDX males. A, Levels of phospho-p42, but not phospho-p44, ERK were significantly increased by E2 in OVX females but not sham males. B, E2 also significantly increased DH phospho-Akt levels in females but not males. Representative blots are shown below both graphs; *p < 0.05 relative to the same-sex vehicle-infused group. Each bar represents the mean +/− SEM. Wendy A. Koss et al. eNeuro 2018;5:ENEURO.0267-18.2018 ©2018 by Society for Neuroscience